期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

NAD^+/NADH代谢机制研究进展 被引量：12

Recent Progress of NAD^+/NADH Metabolism
下载PDF
导出
摘要 NAD+/NADH是细胞能量代谢所必需的辅酶,小到细胞的各种生命活动,大到整个生命结构的平衡,都需要能量来维持。同时,细胞的氧化还原状态,特别是NAD+/NADH的水平直接影响着细胞的节律、衰老、癌变和死亡等重大生命过程。故而有关细胞内NAD+或NADH代谢的研究近年在国际上形成了一个新的热点。我们以NAD+/NADH代谢为重点,综述国内外关于该机制的研究现状。 NAD＋/NADH is a kind of necessary coenzyme in cellular energy metabolism,which is indispensable to all kinds of activity of life phenomenon and balance of life.In addition,it has been shown by numerous studies that cellular redox state especially NAD＋/NADH level may be a primary control site in numerous biological process linked to rhythm,senescence,cancer and death.In the last 10 years,this area of NAD＋/NADH has become an international hot spot of investigation.In this article we mainly reviewd the NAD＋/NADH mechanisms at home and abroad.
作者 李达 伦永志 周士胜
机构地区 大连大学医学院医学研究中心
出处 《生物技术通讯》 CAS 2010年第1期98-102,共5页 Letters in Biotechnology
基金 国家自然科学基金(30570665)
关键词 NAD+ NADH 代谢 NAD＋ NADH metabolism
分类号 Q552 [生物学—生物化学]
  • 相关文献

参考文献45

  • 1Hassanain H H, Chon S Y, Gupta S L. Differential regulation of human indoleamine 2,3-dioxygenase gene expression by interferons-gamma and-alpha. Analysis of the regulatory region of the gene and identification of an interferon-gamma-inducible DNA-binding factor [J]. J Biol Chem, 1993,268(7): 5077-5084.
  • 2Berger F, Lau C, Dahlmann M, et al. Subcellular compartmentation and differential catalytic properties of the three human nicotinamide mononueleotide adenylyltransferase isoforms [J]. J Biol Chem, 2005,280(43):36334-36341.
  • 3Kurnasov 0 V, Polanuyer B M, Ananta S, et al. Ribosylnicotinamide kinase domain of NadR protein: identification and implications in NAD+ biosynthesis[J]. J Bacteriol, 2002,184(24): 6906-6917.
  • 4Bieganowski P, Brenner C. Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss- Handler independent route to NAD+ in fungi and humans [J]. Cell, 2004,117(4):495-502.
  • 5Sauve A A, Wolberger C, Schramm V L, et al. The biochemistry of sirtuins[J]. Annu Rev Biochem, 2006,75:435-465.
  • 6Schreiber V, Dantzer F, Ame J C, et al. Poly(ADP-ribose): novel functions for an old molecule[J]. Nat Rev Mol Cell Biol, 2006,7(7):517-528.
  • 7Graziani G, Szabo C. Clinical perspectives of PARP inhibitors [J]. Pharmacol Res, 2005,52(1):109-118.
  • 8Olgun A.Converting NADH to NAD+ by nicotinamide nucleotide transhydrogenase as a novel strategy against mitoehondrial pathologies during aging[J]. Biogerontology, 2009,10(4):531-534.
  • 9Howard M, Grimaldi J C, Bazan J F, et al. Formation and hydrolysis of cyclic ADP-ribose catalyzed by lymphocyte antigen CD38[J]. Science, 1993,262(5136):1056-1059.
  • 10Hirata Y, Kimura N, Sato K, et al. ADP ribosyl cyclase activity of a novel bone marrow stromal cell surface molecule BSTl[J]. FEBS Lett, 1994,356(2-3):244-248.

同被引文献130

引证文献12

二级引证文献47

生物技术通讯
2010年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部