摘要
目的研究中药清开灵注射液防治小鼠酒精中毒性肝损伤的作用.方法采用Wistar♂大白鼠40只,随机分为正常喂养组10只,单纯酒精损伤组(正常喂养外每日灌注白酒)15只,清开灵注射组(除上述处理外,每日皮下注射清开灵1mL)15只.连续观察12wk后,将上述3组动物全部处死,对其肝脏做病理组织学检查,并测血中肝功及血脂.结果正常喂养组和清开灵注射组肝脏病理组织学、血清肝功及血脂检查近似,而单纯酒精损伤组病理学检查与血清肝功、血脂均有异常,其肝功与血脂与正常喂养组相比有明显差异(P<005及P<001).结论清开灵有较好的防治酒精性肝损伤作用,值得临床推广应用.
AIM To study the protective and therapeutic effects of Qingkailing injection on liver alcoholic liver injury in rats. METHODS At random 40 Wistar male rats were divided into three groups. The normaly fed group included 10 rats which were normaly fed. In the alcohol damaged group 15 rats were normaly fed with alcohol. The Qingkailing group included 15 rats given normal food plus alcohol and Qingkailing injection. All the rats were sacrified after 12 weeks treatment and pathologic examinations of their livers and laboratory examinations including liver function and blood lipoid, were carried out for comparison. RESULTS The liver pathology and liver function and lipoid were similar in normaly fed group and Qingkailing group. While in alcohol damaged group they were obviously abnormal as compared with normaly fed group and Qingkailing group ( P <0 05 and <0 01, respectively). CONCLUSION Qingkailing has a better protective and therapeutic effect in alcoholic liver injury.
关键词
肝疾病
酒精性肝疾病
治疗
病理学
liver disease, alcololic/therapy
liver disease, alcololic/pathology
drugs, Chinese herbal