益气通降方治疗反流性食管炎45例临床观察

Clinical observation of "Yiqi Tongjiang Decoction" in treating reflux esophagitis in 45 cases

目的观察益气通降方治疗反流性食管炎的临床疗效。方法将90例患者随机分为治疗组(45例)和对照组(45例),治疗组予益气通降方,对照组予埃索美拉唑。两组均治疗3个月,观察临床症状疗效、内镜疗效以及治疗前后临床症状积分变化情况。结果治疗组、对照组临床症状总有效率分别为97.78%和91.11%,组间疗效比较,差异有统计学意义(P<0.05)。治疗后治疗组各项临床症状积分和总积分均显著降低(P<0.05);对照组除胸痛积分无明显改善外,其余积分均明显降低(P<0.05);组间治疗后比较,烧心、反胃积分和总积分差异有统计学意义(P<0.05)。治疗组、对照组内镜总有效率分别为77.78%和86.67%,组间内镜疗效差异无统计学意义(P>0.05)。结论益气通降法治疗反流性食管炎疗效确切。

Objective To observe the clinical effects of ＂Yiqi Tongjiang Decoction＂ in the treatment of reflux esophagitis （ RE ）. Methods Ninety subjects were radomized divided into two groups： treatment group in which 45 cases were treated by ＂Yiqi Tongjiang Decoction＂ and control group in which 45 cases were treated by esomeprazole, with a course of three months. The clinical efficacy, endoscopic results and symptom scores were observed before and after treatments. Results The total effective rate was 97.78% in the treatment group and 91.11% in the control group, with a difference between the two rates（P 〈0.05）. After treatments, the symptom scores were reduced in the treatment groups （P 〈0.05 ） ; except heartburn, the other symptom scores were reduced in the control group （P 〈0.05 ） ; the symptom scores of heartburn and regurgitation and total score were reduced more significantly in the treatment group than in the control group （P 〈0.05）. The total effective rate for endoscopic results was 77.78% in the treatment group and 86.67% in the control group, with no difference between the two rates（P 〉0.05）. Conclusion ＂Yiqi Tongjiang Decoction＂ has positive effects on reflux esophagitis.