香草醛缩多胺Schiff碱Cu(Ⅱ)配合物的固相合成、表征及其稳定性和抑菌活性

Solid State Synthesis,Characterization and Stability and Antibacterial Activity of Cu(Ⅱ) Schiff Base(Vanilline Polyamine) Complexes

为Schiff碱Cu(Ⅱ)配合物稳定性与抑菌活性之间的关系提供理论和实验上的依据,以香草醛为原料,分别与乙二胺、二乙烯三胺、三乙烯四胺合成3种Schiff碱配体L1,L2和L3,在室温下与醋酸铜进行固相合成,得到3种新的Schiff碱Cu(Ⅱ)配合物。通过元素分析、红外光谱(IR)、热重(TG-DTA)、分光光度法等测试手段进行了表征。在400nm工作波长下,测定配合物的稳定常数,分别为1.24×104、0.93×104和0.71×104,结果表明:Cu(Ⅱ)与配体L1,L2和L3之间分别形成了1∶1,1∶2和1∶2型配合物,且配合物的稳定性随配体中R基的增大而减小。对Schiff碱配体及其相应配合物进行了抑菌活性实验,结果表明:配体和Cu(Ⅱ)配合物对大肠杆菌、枯草杆菌和八叠球菌均有一定的抑制作用,而且配合物比相应配体的抑菌活性强,配合物稳定性越强,其抑菌活性越强。

Three Sehiff base ligands L1 ,L2 and L3 were synthesized by vanillin and 1,2-ethylenediamine, diethylenetriamine or triethylenetetramine. Three new corresponding Cu （Ⅱ） complexes derived from schiff base ligands and cupric acetate were synthesized by solid state reaction at room temperature. These compounds were characterized by elemental analysis, IR spectra,TG/DTA analysis and spectrophotometry. The stability constant of the complexes were determined at 400nm wavelength. The stability constants are 1.24 × 10^4 , 0.93 × 10^4 and 0.71 × 10^4 , respectively. The results indicate that three new complexes of the type 1 ： 1,1 ： 2 and 1 ： 2 have formed by Cu （Ⅱ） and ligands L1, L2, L3, and the stability of the complexes decreases with the increase of alkyl. The antibacterial activity tests on E. Coil,B. Subtilis and S. Lutea of three ligands and three Cu（Ⅱ） complexes were carried out. The results indicate that all compounds can inhibit three kinds of bacteria and the three Cu（Ⅱ） complexes exhibited the higher biological activity being compared with three ligands. The antibacterial activity of three complexes increases with the increase of their stability.