摘要
目的:探讨原发性高血压病(EH)患者的脉压指数(PPI)与血浆内皮素一1(ET一1)的相互关系。方法:146例EH患者,行24h动态血压监测,计算PPI值,根据PPI值分为三组,PPI〈0.35为A组,PP10.35~0.45为B组,PPI〉0.45为C组。正常体检者64例为对照组(D组)。四组研究对象均抽血化验血浆ET一1。结果:与对照组相比高血压患者血浆ET一1明显增加(P〈0.05)。而EH患者随着PPI的增加,ET—1增加更明显(P〈0.05),相关分析显示PPI与ET—1呈正相关(P〈0.01)。结论:EH患者PPI和血浆ET一1明显增加。
Objective:To observe the relationship between pulsepressure index(PPI) and endothelin 1 (ET-1) in patients with essential hypertension (EH). Methods:Tenty-four hours ambulatory blood pressures (24 h APP)were monitored. 146 patients were divided into three groups according to the level of PPI :PPI0.35 were defined group A. PPI 0.35~0.45 were defined group B. PPI〉0. 45 were defined group C. 64 normal people were defined group D,contrast group. All patients selected and normpeople was observed their levels of plasma endothelin-1 (ET-1). Results: There were significant increases in plasma ET-1 in patients with EH compared with contrast group(P〈0.05). In patients with EH,the ET-1 were significantly different among the subgroups of PPI (P〈0.05). The ET-1 were positive- ly correlated to the PPI(P〈0.01). Conclusion:There were significant increases PPI and in plasma ET-1 in patients with EH.
出处
《临床医药实践》
2010年第2期98-99,共2页
Proceeding of Clinical Medicine
关键词
原发性高血压
脉压指数
内皮素-1
essential hypertension tpulse pressure index
endothelin-1