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羟丁酸钠对瑞芬太尼镇痛作用的影响

The enhanced effect of sodium oxybate on the analgesia of remifentanil
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摘要 目的观察羟丁酸钠对瑞芬太尼镇痛效果的影响。方法试验小鼠48只,随机分为热板法试验组(n=24,均为雌性)和扭体法试验组(n=24,雌雄各半),各组再按分层随机区组设计各分为甲组(羟丁酸钠和生理盐水合用组)、乙组(瑞芬太尼和生理盐水合用组)和丙组(羟丁酸钠和瑞芬太尼合用组),分别以热板法和扭体法观察羟丁酸钠对瑞芬太尼镇痛小鼠热板法痛阈(HPPT)和扭体次数的影响。结果热板法试验提示,与丙组相比,甲组和乙组在5、10和20 min时HPPT均降低,5和20 min时降低显著(P<0.01)。扭体试验结果显示,与丙组相比,甲组和乙组小鼠扭体次数增加,差异显著(P<0.01)。结论羟丁酸钠可增强瑞芬太尼的镇痛效应。 Objective To observe the effect of sodium oxybate on the analgesia of remifentanil. Methods Forty eight mice were randomly divided into 2 groups, to be treated by hot-plate method (n=24) and stretching method (n=24). Both groups were randomly divided into group A (sodium oxybate+ sodium chloride), group B (remifentanil+sodium chloride) and group C (sodium oxybate+remifentanil). Pain threshold in hot-plate test (HPPT) and the number of stretching times were observed. Results Compared with group C, HPPT at 5 and 20 min in group A or group B decreased significantly (P〈0.01), and the number of stretching times in group A or group B increased significantly (P〈0.01). Conclusion Sodium oxybate can enhance the analgesia effect of remifentanil.
出处 《世界临床药物》 CAS 2010年第2期83-85,共3页 World Clinical Drug
基金 国家自然科学基金资助项目(30872432 30471657 39970715) 江苏省自然科学基金资助项目(BK200143)
关键词 羟丁酸钠 瑞芬太尼 镇痛 联合用药 sodium oxybate remifentanil analgesia drug combination
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