闭式引流联合尿激酶及白介素-Ⅱ治疗恶性包裹性胸腔积液

Combination of closed thoracic drainage with Urokinase and IL-Ⅱ in treating encapsulated malignant pleural effusion

目的观察胸腔闭式引流联合尿激酶及白细胞介素-Ⅱ治疗恶性包裹性胸腔积液的疗效。方法对26例恶性包裹性胸腔积液患者应用中心静脉导管胸腔穿刺置管引流,胸水自然流净后,胸腔注入尿激酶20万U,闭管30 min,再打开引流装置持续引流。可重复上述操作。胸水引流完全后,胸腔注入白细胞介素-Ⅱ200万U。结果完全缓解(CR)21例,部分缓解(PR)5例。不良反应轻,以一过性发热为主要反应。结论胸腔闭式引流联合尿激酶及白细胞介素-Ⅱ治疗恶性包裹性胸腔积液安全、有效。

Objective To observe the therapeutic effects of closed thoracic drainage combined with Urekinase and IL-Ⅱ for encapsulated malignant pleural effusion. Methods 26 patients with encapsulated malignant pleural effusion were treated with closed thoracic drainage by central venous catheter. After natural drainage of pleural effusion 200 000 U Urokinase were injected through thoracic cavity, then closed the tube. Half an hour later, open the drainage tube again. Repeat the above operation. When the effusion were drained completely,2 000 000 U IL- Ⅱ were injected through thoracic cavity. Results Complete remission （CR） 21 cases,Partial remission （PR） 5 cases. Light adverse reactions. Transient fever was the main reaction. Conclusion Combination of closed thoracic drainage with Urokinase and IL - Ⅱ in the treatment of encapsulated malignant pleural effusion is safe and effective.