1Kelleher CM ,Silverman EK,Broekelmann T,et al. A functional mutation in the terminal exon of elastin in severe, early-onset chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol,2005,33 : 355 - 362.
2Hucthagowder V, Sausgruber N, Kim KH, et al. Fibulin-4 :a novel gene for an autosomal recessive cutis laxa syndrome. Am J Hum Genet,2006,78:1075 - 1080.
3Grange DK, Kaler SG, Albers GM, et al. Severe bilateral panlobular emphysema and pulmonary arterial hypoplasia: unusual manifestations of Menkes disease. Am J Med Genet A,2005,139 : 151 - 155.
5Hersh CP, Demeo DL, Lazarus R, et al. Genetic association analysis of functional impairment in chronic obstructive pulmonary disease. Am J Respir Crlt Care Med ,2006,173:977 -984.
6Hersh CP, Dahl M, Ly NP, et al. Chronic obstructive pulmonary disease in alphal-antitrypsin PI MZ heterozygotes: a meta-analysis. Thorax,2004,59 : 843 - 849.
8Juul K,Tybjaerg-Hansen A, Marklund S, et al. Genetically increased antioxidative protection and decreased chronic obstructive pulmonary disease. Am J Respir Crit Care Med ,2006,173:858 -864.
10Ito I, Nagai S, Hoshino Y, et al. Risk and severity of COPD is associated with the group-speciflc component of serum globulin 1F allele. Chest ,2004, 125:63 - 70.
4Celli B R, MacNee W. Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper [J]. Eur Respir J, 2004, 23(6):932-946.
5Richman-Eisenstat J B, Jorens P G, Hebert C A, et al. Interleukin-8: an important chemoattraetant in Sputum of patients with chronic inflammatory airway diseases [J]. Am JPhysiol, 1993, 26(4 Pt1): 413-418.
6Borchers M T, Garty M P, Leikauf G D. Regulation of human airway mucins by acrolein and inflammatory mediators [J]. Am JPhysiol, 1999, 276(4 Pt 1): 549-555.
7Mason K P, Zgleszewski S, Forman R E, et al. An exaggerated hypertensive response to glycopyrrolate therapy for bradycardia associated with high-dose dexmedetomidine [J]. AnesthAnalg, 2009, 108(3): 906-908.
8Rabe K F, Bateman E D, O'Donnell D D, et al. Roflumilast-anoral anti-inflammatory treatment for chronic obstructive pulmonary disease: a randomised controlled trial [J]. Lancet, 2005, 366(4985): 563-571.
9Bousquet J. Mometasone furoate: an effective anti- inflammatory with a well-defined safety and tolerability profile in the treatment of asthma [J]. Int J Clin Pract, 2009, 63(5): 806-819.