大剂量布拉氏酵母菌治疗婴儿急性水样腹泻临床对照研究

High Dose Saccharomyces Boulardii in Treatment of Infants with Acute Watery Diarrhea:A Clinical Controlled Trial

目的:评估大剂量布拉氏酵母菌治疗婴儿急性水样腹泻的疗效。方法:采取历史对照和随机对照临床试验,大剂量治疗组在补液基础上给予蒙脱石散剂和大剂量布拉氏酵母菌冻干制剂(500mg,bid);常规剂量治疗组在补液基础上给予蒙脱石散剂和常规剂量布拉氏酵母菌冻干制剂(250mg,bid);对照组在补液基础上给予蒙脱石散剂和常规剂量双歧杆菌类微生态制剂。结果:大剂量治疗组与常规剂量组比较,显效率存在显著的统计学差异(χ2=5.34,P<0.05),且两组治疗后第1天和第3天大便次数统计分析有显著差异(Z=-2.05、-3.05,P均<0.05)。大剂量治疗组、常规剂量组、对照组患儿平均住院天数分别为3.5±1.3天、4.4±1.8天、5.7±2.1天。大剂量治疗组与常规剂量治疗组比较,平均住院天数统计分析有显著差异(Z=-2.10,P<0.05)。结论:口服大剂量布拉氏酵母菌提高婴儿急性水样腹泻治疗的显效率,减少大便次数,缩短住院天数,产生一定的社会和经济效益。

OBJECTIVE：To evaluate the efficacy of high-dose Saccharomyces boulardii in the treatment of infants with acute watery diarrhea. METHODS： A historical control and randomized controlled clinical trial was conducted in which the infants with acute watery diarrhea were randomized into 3 groups,i.e. high dose treatment group （500 mg Saccharomyces boulardii b.d.d plus Smectite Powder and fluid infusion）,conventional dose group （250 mg Saccharomyces boulardii b.i.d plus Smectite Powder and fluid infusion） and control group. RESULTS： Significant statistical difference was noted between the high dose treatment group and the conventional dose group with regard to the remarkable effective rate （Z=5.34,P〈0.05）. The stool frequency between the high dose treatment group and the conventional dose treatment group were statistically different on day 1 and day 3 after treatment （Z= -2.05 and -3.05,respectively;both P〈0.05）. The average number of hospitalization days in high dose treatment group,conventional dose treatment group and the control group were 3.5 1.3 days,4.4 1.8 days and 5.7 2.1 days,respectively,showing significant differences between the high dose treatment group and the conventional dose treatment group （Z=-2.10,P〈0.05）. CONCLUSION： High dose oral Saccharomyces boulardii can improve the remarkable effective rate in infants with acute watery diarrhea,reduce stool frequency and shorten the number of days of hospitalization,resulting in favorable social and economic benefits.