摘要
从直接法、小分子键合、星形、树枝状和超支化环糊精大分子胶束及水凝胶、超分子组装7方面论述了环糊精-药物纳米复合体的制备,认为扩散控制、溶胀控制和化学控制是环糊精-药物纳米复合体主要的释放机理。结合释放机理,指出具有超分子结构的复合体系可望成为智能靶向释放领域的主导。
The preparation of CDs-drug nanoparticle is summarized from aspects including non-covalent inclusion, covalent conjugate, micelles inclusion of CDs polymer and supramolecular assembly in nano size. Star-shape, dendritic and hyperbranched-CD polymers and CD hydrogel-drug inclusions are described in details. Mechanism of drug controlled release is elucidated in diffusion, target controlled and swelling controlled routes. Combination to drug release mechanisms, CDs-drug complexes integrated supramolecular structure is desired to guide in smart target controlled release.
出处
《材料导报》
EI
CAS
CSCD
北大核心
2010年第5期136-140,共5页
Materials Reports
基金
国家自然科学基金(基金号20674060)
关键词
环糊精
纳米粒子
药控释放
两亲性
包合
cyclodextrins, nanoparticles, drug controlled release, amphiphilicity, inclusion
