幽门螺杆菌与食管相关疾病关系研究进展

Advances in Studies on Relationship between Helicobacter Pylori and Oesophagus-associated Diseases

幽门螺旋杆菌（Helicobacter pylori，Hp）是一种定植在人胃黏膜上的微需氧致病茵，目前已经证实：Hp与人类的慢性胃炎、消化性溃疡密切相关，同时又是引起胃癌和胃黏膜相关淋巴瘤的危险因素。随着对Hp致病机制研究的深入，近年来Hp与食管相关疾病如胃食管反流病（gastro esophageal reflux disease，GERD），Barrett食管以及食管癌之间的关系也受到越来越多的关注，研究提示Hp在GERD及Barrett食管的发生中可能起保护作用，但研究结论尚存在争议，同时目前初步研究提示Hp与食管癌的发生有一定的关系，可能是其危险因素之一。

Helicobacter Pylori（Hp）is a kind of bacterial which is gramstaining negative and Microaerophilic,and colonization in human gastric mucosa. It has been confirmed that Hp is not only closely related to Chronic gastritis and Peptic ulcer,but also the risk factors of gastric cancer and gastric mucosa-associated lymphoid. In recently years,with deeply study of the pathogenic mechanism of Hp,more and more attention are paid to the relationship between Hp and esophageal-associated diseases such as esophageal reflux disease （gastro esophageal reflux disease,GERD）. Barrett esophagus and esophageal cancer,most research suggests that Hp in the incidence of GERD and Barrett esophagus may play a protective effect ,but some inconsistent findings,conclusions remaining in dispute,while the preliminary research suggests that Hp is related with esophageal cancer ,it may be the risk factor of esophageal cancer.