流感病毒疫苗的研究现状与安全性验证

Influenza Virus Vaccine Present Situation of Research and Safety Test

流行性感冒(简称流感)是由流感病毒(Influenza virus,IFV)引起的一种急性呼吸道传染病,严重危害人类健康和生命,目前,临床上使用的抗流感病毒药物主要有M2离子通道抑制剂和神经氨酸酶抑制剂,接种流感疫苗仍然被认为是预防流感发生与传播的最佳方法。从1933年Smith等首次从雪貂体内分离到流感病毒以来,人们就一直在进行流感疫苗的研究。笔者对流感疫苗的研究现状、研制流程、安全性和有效性的验证等多方面进行综述,为今后对流感疫苗做更进一步的研究提供了很好的基础。

Influenza （the flu）is a flu virus （Influenza virus, IFV） caused an acute respiratory infectious diseases, serious harm to human health and life, at present, the clinical use of anti -influenza virus drug major inhibitor of M2 ion channel and the neuraminidase inhibitors, influenza vaccination is still considered to prevent the spread of influenza occurrence and the best way. From the first time in 1933, Smith, etc. isolated from ferrets to influenza virus in vivo, there has been on the influenza vaccine has been engaged in research. In this paper, the status of influenza vaccine research, development process, the safety and test of effectiveness and so forth execute on the elaboration variously,vaccines for the future role of further research provided a good foundation.