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SLC30A8基因单核苷酸多态性与2型糖尿病相关性的研究进展 被引量：1

Recent Progress on SLC30A8 Gene Polymorphism and Type 2 Diabetes Mellitus
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摘要 2型糖尿病具有明显的遗传倾向,是一种复杂的多基因遗传病。SLC30A8基因位于8q24.11,编码的蛋白为ZnT-8,其特异性地在胰腺内分泌细胞表达,与胰岛素的储存和分泌有关,其风险等位基因是迄今发现的与2型糖尿病的发生关联比较强的变异。近年来,许多学者致力于研究SLC30A8基因变异型增加2型糖尿病易感性的机制。 Type 2 diabetes mellitus （T2DM）has a genetic tendency obviously, it is a complicated muhi-gene heredopathia. SLC30A8 gene,located in 8q24.11 ,which encodes ZnT-8. The zinc transporter ZnT8 is specifically expressed in pancreatic endocrine cells,it was related to storage and secretion of the Insulin. It has been found that the risk allele of SLC30A8 was one of the most closely connected with T2DM up to today. Recently, many scholars have been researching the reason that variation of SLC30A8 can increase the impressionability of T2DM.
作者 李晶 王建平
机构地区 南华大学附属第二医院内分泌科
出处 《医学综述》 2010年第7期989-991,共3页 Medical Recapitulate
关键词 2型糖尿病 SLC30A8基因 单核苷酸多态性 Type 2 diabetes mellitus SLC30A8 gene Single nucleotide polymorphism
分类号 R587.1 [医药卫生—内分泌]
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医学综述
2010年 第7期

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