卒中后抑郁和脑卒中患者血脂水平对照研究

A control study of levels of serum lipid in patients with post-stroke depression and brain stroke

目的探讨卒中后抑郁(PSD)及脑卒中患者血脂水平的差异,为其临床诊治寻找更多的实验室依据。方法对50例PSD及50例脑卒中非抑郁患者分别进行血脂检测,并将结果与对照组进行比较。结果PSD患者血清总胆固醇(TC)水平高于对照组和脑卒中组,差别有统计学意义(P<0.01),而血清甘油三酯(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)与脑卒中组和对照组比较差别无统计学意义(P>0.05);脑卒中组与对照组各指标比较差别无统计学意义(P>0.05);相关分析显示PSD组患者的TC与汉密尔顿抑郁量表(HAMD)得分及自评抑郁量表(SDS)得分呈显著正相关(r=0.34和0.37,P<0.01),其余血脂指标浓度与量表测定得分无相关性(P>0.05)。结论TC水平测定可作为PSD患者的诊断和治疗指标应用于临床。

Objective To explore the difference of serum lipid levels in patients with post-stroke depression（PSD） and brain stroke.Methods Serum lipid levels were test in fifty PSD and fifty brain stroke patients,and the results were compared with the control group.Results Serum total cholesterol levels of PSD group were signiffcantly higher than that of brain stroke group and control group（P0.01）.The levels of triglyceride（TG）,high density lipoprotein-C（HDL-C）,low density lipoprotein-C （LDL-C） of PSD group were compared with the brain stroke group and control group,and there were no statistic difference between them（P0.05）.There were no statistic difference of TC,TG,HDL-C,LDL-C between brain stroke group and control group（P0.05）.Correlation analysis showed that there was a remarkable positive correlation with TC levels and the scores of scale of Hamilton Depression（HAMD）,Self-Rating Depression（SDS）（P0.01 ） in PSD group;The other indexes of serum lipid had no correlation with the scores of the two scales in PSD group（P0.05）.Conclusion TC level test can be used as indicators for diagnosis and treatment of patients with PSD.