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牙周局部缓释型制剂的研究现状及应用进展 被引量:18

Research status and application progression in periodontal locally sustained-release antimicrobials
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摘要 背景:局部应用缓释剂辅助治疗牙周病是近年来牙周药物治疗研究中的一个活跃领域,其中剂型、药物和载体材料方面的研究都有了很大进展。目的:对国内外应用牙周局部缓释剂的现状及新进展作一综述。方法:应用计算机检索CNKI和Pubmed数据库中1999-01/2009-10关于牙周局部缓释剂的文章,在标题和摘要中以"牙周炎,治疗,药物,缓释"或"periodontitis,treatment,medications,sustained-release"为检索词进行检索。选择内容与牙周局部缓释剂有关的文章,同一领域则选择近期发表或发表在权威杂志文章。初检得到143篇文献,根据纳入标准选择40篇文献进行综述。结果与结论:牙周局部缓释剂的应用对临床上一些特殊牙周炎的治疗起到了很好的辅助作用,其以用药量小、作用时间长、靶向作用好等特点被广泛关注,尤其随着复合药物和牙周组织再生研究的发展,牙周局部缓释剂在临床治疗中的应用必将更加广泛。 BACKGROUND:Local application of sustained-release antimicrobials serve as an adjuvant therapy of periodontitis,and the dosage form,medicine and carrier material have greatly developed.OBJECTIVE:To summarize the current situation and progression of periodontal local sustained-release antimicrobials at home and abroad.METHODS:A computer-based online search of CNKI and Pubmed(1999-01/2009-10)was performed for the related articles about sustained-release antimicrobials,with the Keywords"periodontitis,treatment,medication,and sustained-release".The articles in the same field published recently or in authoritative journals were selected.A total of 143 articles were collected,and 40 related sustained-release antimicrobials were included.RESULTS AND CONCLUSION:Application of sustained-release antimicrobials is a well adjuvant therapy for some special clinical periodontitis.It is widely used due to its low dosage,long lasting-time and well target effect.The clinical application of sustained-release antimicrobials is promising along with the development of compound medicine and periodontal tissue regeneration.
作者 王聃 邓嘉胤
出处 《中国组织工程研究与临床康复》 CAS CSCD 北大核心 2010年第8期1437-1441,共5页 Journal of Clinical Rehabilitative Tissue Engineering Research
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