摘要
目的比较波依定、洛汀新、倍他乐克对轻中度原发性高血压患者的降压疗效。方法采用随机、单盲的方法分3组治疗,运用偶测及动态血压监测结果分析疗效。结果以偶测血压观察3组的降压效果,3组降低清晨平均血压的作用均无显著差异。波依定组降低白昼平均和全天24 h平均血压的幅度大于洛汀新、倍他乐克组。波依定组降压总有效率为91%,洛汀新组降压总有效率为87.7%,倍他乐克组总降压有效率为82.3%。结论3组药物均能有效降低血压,以波依定组起效较快,降低白昼及全天平均血压幅度优于洛汀新、倍他乐克组,但3组相比差异无统计学意义(P>0.05)。
Objective To compare the antihypertensive effects of plendil,benazepril or betaxolol on mild to moderate primary hypertension.Methods Ninety patients were enrolled in this random,single-blinded study.Blood pressure was measured by occasional measurements or ambulatory blood pressure monitoring.Results According to occasional measurements,there were no significant differences in the antihypertensive effects and the mean morning blood pressure among three groups.But according to ambulatory blood pressure monitoring,the mean blood pressure during daytime and during 24 hours in Plendil group was lower than that in benazepril or betaxolol group.Conclusion The overall response rate was 91.0%in plendil group,87.7% in benazeprll group and 82.3% in betaxolol group.Three drugs can decrease blood pressure effect,antihypertensive effects is stronger than benazepril or betaxolol during daytime and during 24 hours,but the differences are not significant(P0.05).
出处
《中国实用神经疾病杂志》
2010年第7期18-20,共3页
Chinese Journal of Practical Nervous Diseases