国产rhFSH与果纳芬对排卵障碍患者促排卵的临床观察

The clinical observation of ovulation induction effect with domestic rhFSH and Gonal-F on ovulation disorders

目的:比较国产重组人促卵泡激素(rhFSH)(金赛药业)与果纳芬(雪兰诺公司)对排卵障碍的不孕患者促排卵治疗的疗效,评价国产rhFSH的治疗作用,了解卵泡生长速率及生殖内分泌激素水平变化的规律。方法:将排卵障碍不孕患者54例随机分为A组34例、B组20例,进行促排卵治疗,A组给予国产rhFSH促排卵,B组给予果纳芬促排卵,观察两组疗效。结果:A、B两组的用药总量、平均每日用药量、平均促排卵天数、HCG日≥18mm卵泡数目、优势卵泡平均生长速率、HCG日血E2、LH、P水平、HCG日子宫内膜厚度、排卵后6d的P值、排卵率、妊娠率、分娩率分别为(1062.5±505.7)(375～2175)IU和(1157.5±470.6)(375～2325)IU;(105.8±28.2)(75～150)IU和(114.9±30.3)(75～150)IU;(10.0±4.3)(5～20)d和(10.4±4.0)(5～20)d;(1.3±0.7)个和(1.3±0.6)个;(1.7±0.2)mm/d和(1.5±0.2)mm/d;(2283.1±2350.0)pg/mL,(6.9±5.4)pg/mL,(1.4±1.2)ng/mL和(2098.2±2454.2)pg/mL,(8.4±5.8)pg/mL,(1.3±0.8)ng/mL;(10.7±0.4)mm和(10.3±0.7)mm;(31.7±37.8)ng/mL和(33.3±29.1)ng/mL;82.4%和90.0%;17.6%和25.0%,66.7%和80.0%(P>0.05)。结论:国产rhFSH具有良好的促排卵疗效,身体反应过程一致,作用不弱于果纳芬。

Objective：To compare ovulation induction effect of domestic rhFSH（GenSci）and Gonal-F（Serono）on ovulation disorders,and evaluate the effect of rhFSH on follicular growth and reproductive hormones.Methods：Fifty-four infertility women with ovulatory disorde were randomly divided into A and B group.Group A（34 cases）was treated with domestic rhFSH,and group B（20 cases）with Gonal-F.Results ：The total administration,daily dosage,average ovulation days,number of follicles greater than 18 mm,follicular development velocity,blood estrodiol,lutinizing hormone,progesterone level on HCG day,endometrial thickness on HCG day,progesterone level after ovulation for 6 days,ovulation rate,pregnancy rate of group A and B were 1062.5±505.7（375-2175）IU VS 1157.5±470.6,（375-2325）IU;105.8±28.2,（75-150）IU VS 114.9±30.3,（75-150）IU;10.0±4.3,（5-20）day VS 10.4±4.0,（5-20）day;1.3±0.7VS1.3±0.6;（1.7±0.2）mm/d VS（1.5±0.2）mm/d;（2283.1±2350.0）pg/mL,（6.9±5.4）pg/mL,（1.4±1.2）ng/mL VS（2098.2±2454.2）pg/mL,（8.4±5.8）pg/mL,（1.3±0.8）ng/mL;（10.7±0.4）mm VS（10.3±0.7）mm;（31.7±37.8）ng/mL VS（33.3±29.1）ng/mL ;82.4% VS 90%;17.6% VS 25%;66.7% VS 80%（P〉0.05）.Conclusion：Domestic rhFSH is as effective as t Gonal-F.