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食管癌后程加速超分割放疗加同期化疗的临床疗效观察 被引量:5

Clinical Efficacy of Combination of Late Course Accelerated Hyperfrationation Radiotherapy with Chemotherapy in Treating Esophageal Carcinoma
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摘要 目的比较后程加速超分割放疗加同期化疗与单纯后程加速超分割放疗治疗食管癌的疗效.方法36例中上段食管癌病人随机分为两组:后程加速超分割放疗(LCAFR)组18例,首先予前后野对穿照射,分割剂量2 GY/次,5次/周.DT40 GY后避开脊髓,分割剂量1.2 GY/次,2次/d(间隔6 h以上),使肿瘤总量达65 GY左右.后程加速超分割放疗加同期化疗(LCAFR+C)组18例,同LCAFR组并加用顺铂40 mg静滴,第1~3天;5-氟尿嘧啶3 g,持续泵5 d,共两周期.结果放化组和单放组的1、3 a生存率分别为83.3%、77.7%和38.9%、33.4%,但差异无统计学意义(P>0.05);放化组和单放组1,3 a局部控制率分别为88.9%、72.2%和61.1%、38.9%,差异无统计学意义(P>0.05).结论后程加速超分割放射治疗加化疗未能明显提高食管癌放射治疗的生存率,有提高食道癌的局部控制率的趋势. Objective To compare the clinical efficacy of late course accelerated hyperfractionation radiotherapy plus chemotherapy(LCAHR+C) and late course accelerated hyper fractionation radiotherapy(LCAHR).Methods 36 patients with mid-upper segment esophageal carcinoma were randomly divided into two groups:(1) LCAFR group:18 patients received 2 Gy per day,5 times a week,till DT 40 Gy.Then traditional radiotherapy was applied and kept away with vertebral canal,1.2 Gy per fraction,2 times per day(interval of six hours),to a total dose of 65 Gy.(2) LCAHR+C group: 18 patients received the same radiotherapy as LCAHR,supplemented with concurrent chemotherapy.The chemotherapy scheme was consecutive intravenous infusion of cisplatin(DDP) 40mg/d for days1 ~3 and consecutively pumping of 5-fluorouracil(5-Fu) 3g for 5 days.It was given 2 cycles.Results The survival rate of 1-year and 3-year in LCAFR+C group and in LCAFR group was 83.3%,77.7% and 38.9%,33.4% respectively.There was no significant difference between two groups(P0.05).The local control rate of 1-year and 3-year in LCAFR+C group and in LCAFR group was 88.9%,72.2% and 61.1%,38.9% respectively.There was no significant difference between two groups(P 0.05).Conclusion LCAHR plus concurrent chemotherapy can not significantly improve the survival rate of patients with esophageal cancer but has a tendency to improve the local control rate of esophageal cancer.
出处 《昆明医学院学报》 2010年第3期66-68,共3页 Journal of Kunming Medical College
关键词 食管癌 放疗 化疗 Esophageal carcinoma Radiotherapy Chemotherapy
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