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生命科学研究中常用模式生物 被引量:24

Model Organism Commonly Used in Life Science Research
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摘要 模式生物是生命科学研究的重要材料,目前公认的用于生命科学研究的常见模式生物有噬菌体、大肠杆菌、酵母、线虫、果蝇、斑马鱼、小鼠、拟南芥等.这8种常用模式生物对生命现象的揭密和人类疾病治疗的探索等都所做出了重大贡献,对其在生命科学研究中的历史轨迹、各自优势、技术手段、热点研究、发展前景等系统而又简要的了解,有助于具体而又生动地体察到模式生物在今天生命科学发展中的重要地位和推动生命科学及医学进步的不可替代的巨大潜力. Model organisms are important materials for life science research. Currently, Bacteriophage, Escherichia coli, Sacharomyces cerevisiae, Caenorhabditis elegans, Drosophila melanogaster, Danio rerio, Mus musculus, A rabidopsis thaliana are widely recognized as model organisms for life science research. These model organisms have made significant contribution to the exploring of biological phenomena and human disease treat. Giving a system and brief introduction for the history, advantages, technical means, research focuses and development prospects of the eight model organisms commonly used in scientific research, so we can easily understand their important role in the development of life science research and great irreplaceable potential in the progress of life sciences and medical.
作者 王凯
出处 《生命科学研究》 CAS CSCD 2010年第2期156-165,共10页 Life Science Research
基金 2008年度中国水稻研究所自主研究课题(ZZKT200801)
关键词 模式生物 分子生物学 功能基因组 model organism molecular biology functional genomic
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  • 1Mattingly CJ, Toscano WA. Posttranscriptional silencing of cytochrome P4501A1 (CYP1A1) during zebrafish (Danio rerio) development. Dev Dyn, 2001,222:645-54
  • 2Norback DH, Allen JR Biological responses of the nonhuman primate chicken, and rat to chlorinated dibenzo-p-dioxin ingestion. Enuiron Health Perspect, 1972, 5:233-240
  • 3Toborek M, Barger SW, Mattson M P, et al.Exposure to polychlorinated biphenyls causes endothelial cell dysfunction. J Biochem Toxicol,1995, 10: 219-226
  • 4Westerfield M. The Zebrafish Book, University of Oregon Press, Eugene.1993
  • 5Cantrell SM, Joy-Schlezinger J, Stegeman JJ, et al. Correlation of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced apoptotic cell death in the embryonic vasculature with embryotoxicity. Toxicol Appl Pharmacol, 1998, 148, 24-34
  • 6Belair CD, Peterson RE, Heideman W. Disruption of erythropoiesis by dioxin in the zebrafish. Dev Dyn, 2001,222,581-94
  • 7Cantrell SM, Lutz LH, Tillitt DE, et al. Embryotoxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD): the embryonic vasculature is a physiological target for TCDD-induced DNA damage and apoptotic cell death in Medaka (Orizias latipes). Toxicol Appl Pharmacol, 1996 , 141, 23-34
  • 8Collins TF. Teratological research using in vitro systems. V. Nonmammalian model systems. Environ Health Perspect, 1987 , 72, 237-49
  • 9Couture LA, Abbott BD, Birnbaum LS. A critical review of the developmental toxicity and teratogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin: recent advances toward understanding the mechanism. Teratology, 1990, 42, 619-27
  • 10Dong W, Teraoka H, Kondo S, et al. 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin induces apoptosis in the dorsal midbrain of zebrafish embryos by activation of arylhydrocarbon receptor. Neurosci Lett, 2001,11,303,169-72

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