结直肠癌预后因素与治疗

Survival analysis of 333 colorectal cancer patients

目的:了解结直肠癌的预后因素与治疗现状。方法:回顾性分析我院2000年1月-2005年12月收治的333例结直肠癌患者的临床资料,观察临床病理特征和治疗方案对预后的影响。结果:K-M单因素分析显示结直肠癌的预后因素是症状、症状持续时间、术前CEA水平、分期、部位、肿瘤大小、病理分级、病理分型、是否联合化疗、Ⅲ期患者是否行辅助化疗、晚期结直肠癌治疗模式、直肠癌治疗模式;COX模型多因素分析显示影响生存的独立因素为术前CEA水平、分期、是否联合化疗、直肠癌治疗模式;333例结直肠癌患者的平均生存期为58.365±2.159个月,1年、3年、5年生存率分别为82.47%、63.48%和56.60%,其中综合治疗患者占46.39%,单纯手术患者占51.20%。结论:治疗模式是结直肠癌重要的独立预后因素,而标准的治疗模式应该得到进一步的重视和应用。

Objective：To understand the factors affected the prognosis of colorectal cancer and the outcome of therapy. Methods：To observe the relationship between clinicopathological characteristics and prognosis of 333 color- ectal cancer patients by retrospective analysis. Results： Symptom, time going on, preoperative CEA level, staging, lo- cation, tumor size, tumor discrimination, pathological typing, chemotherapy, radiotherapy were related to the prognosis of colorecta] cancer by K - M univariate analysis, for further analysis by COX model, preoperative CEA level, staging, chemotherapy, radiotherapy were independent factors affecting the prognosis of patients. The average of overall survival of 333 colorectal cancer patients was 58. 365 ＋ 2. 159 months, one -year,three -year ,five -year survival rates sepa- rately were 82.47% ,63.48% and 56.60%. Patients with combined therapy and single therapy separately occupied 46.39% and 51.20%. Conclusion：The therapy model is an important and independent factor affecting the prognosis of colorectal cancer patients, so the standard therapy model should be paid attention and used.