麻疹　流行性腮腺炎　风疹活疫苗(M-M-RⅡ)免疫效果观察及免疫程序探讨

Immune Effect Survey and Immunization Procedure for Measles-Mumps-Rubella Ⅱ Vaccoine

选择在8～9月龄时已完成麻疹减毒活疫苗（MV）初免的11～16月龄儿童为观察对象，对麻疹、流行性腮腺炎（腮腺炎）、风疹活疫苗（M－M－RⅡ）的免疫效果进行了观察，并探讨其免疫程序．M－M－RⅡ免疫后麻疹血凝抑制（HI）抗体阳性率100％，抗体≥4倍增长率为55．42％，几何平均滴度（GMT）1：46．60，较免疫前增长2．27倍；腮腺炎HI抗体阳转率95.23％，GMT1：9．60;风疹HI抗体阳转率100％，GMT1：392．47．作者认为，在上海市M－M－RⅡ初始免疫程序确定为已完成MV初免的12～18月龄儿童是合理的，且能产生理想的免疫效果．

In this survey, the 11-16 months old children who had finished primary measles vaccination at the age of 8-9 months were selected. The immune effect of measlesmumps-rubella Ⅱ (M-M-R Ⅱ) vaccine was observed and it's procedure has been probed into. Seroconversion rate of anti-measles hemaglatination inhibition(HI) antibody was 100%,and the four-fold rise rate of HI antibody was55.42%,the geometric mean titer(GMT) was 1:46.60, which rose 2.27-folds as compared with GMT of prevaccination. Mumps HI antibody seroconversion rate was 95.23% with GMT of 1:9.6. Rubella HI antibody seroconversion rate was 100% with GMT of 1:392.47. The age thought to be rational for children in the initiative procedure of immunization with M-M-R Ⅱ in Shanghai is at 12-18 months old who had been received primary measles virus vaccination, and this procedure will bring about ideal immunological effect.