新生儿乙型肝炎疫苗全程免疫后抗-HBs低应答者的长期随访

Long-term Follow-up of 28 Cases of Low Anti-HBs Response or Nonresponsiveness to Hepatitis B Vaccine

为了解新生儿乙型肝炎（乙肝）疫苗全程免疫后抗－HBs低应答者的再感染情况和转归，为免疫预防措施提供依据，选取乙肝疫苗全程免疫后抗-HBs低应答者28例进行长期血清流行病学随访．结果有12例（42．86％）仍是HBsAg、抗-HBs和抗-HBc三项全阴性，也未发现HBV感染指征；5例（17．86％）出现了单项抗-HBsS／N值≥10．0以上的应答；11例（36．4％）发生HBV感染，其中4例（36．4％）变为持续阳性者，有1例为HBsAg阳性可能仍属母婴阻断失败者。表明抗-HBs低应答是个暂时现象，多数有潜伏感染，但预后是好的．

In order to understand the consequence in newborns of low or nonresponsiveness to hepatitis B vaccine since their birth and were tested to be HBsAg negative, anti-HBs S/N value＜10.0, 28 infants were selected from Xiangtan and Zhengding fields for a long-term follow-up study. The results showed that after a 8.5 year follow-up, 5 of the 28 children showal positive seroconversion of anti-HBs, S/N value ≥ 10.0, 11 children were positive for HBV markers, 4 of them borne persistently positive, 1 of them was HBsAg postive; the other 12 children were sun negative for HBsAg, anti-HBs, anti-HBc and had no indications for HBV infection. The authors suggest that the low or nonresponsiveness to HB vaccine is a transient phenomenon, most of the children had incubation infection, they probably had been infected during the bine of birth becouse most of them were born to HBsAg positive mothers. They will have good prognosis.