帕金森病合并不宁腿综合征的相关因素分析

The relevant factors in patients with Parkinson disease and restless leg syndrome

目的研究帕金森病(Parkinson's disease,PD)患者合并不宁腿综合征(restless leg syndrome,RLS)的特点,进一步探讨PD患者易合并RLS的相关因素。方法选取门诊诊断为PD的102例患者,根据是否合并RLS将入选病例分为不伴RLS的PD组和伴RLS的PD组,分别比较两组的一般状况、病史、临床表现、严重程度评分以及治疗等临床资料,进行单因素统计分析。结果102例PD患者中有28例合并有RLS,发生率为27·5%。其中有1例为诊断PD之前即存在RLS,其余均在出现PD症状后才出现RLS症状。两组在HAMD评分上有统计学差异(P<0.05),而在一般状况,主要症状,左旋多巴的治疗以及蒙特利尔,UPDRS评分等方面均未见统计学差异(P>0.05)。PD患者中RLS的发生与抑郁情绪有着较密切的关系,另外发现PD发病年龄与RLS的严重程度呈负相关。PD患者的发病年龄越小,RLS的程度越严重。结论PD患者抑郁状态时合并RLS的可能性较大。PD合并RLS患者,PD的发病年龄越小,RLS程度越严重。

Objective To study the features of patients with Parkinson＇s disease （PD） and restless legs syndrome （RLS） and to further examine relevant factors for the co-occurrence of PD and RLS.Methods One hundred and two PD patients were recruited in the present study.The RLS screen was further performed in PD patients based on the diagnostic criteria for RLS.PD patients with RLS were designated as the case group and PD patients without RLS served as a control group.The clinical data including general situation,medical history,clinical manifestations,severity score and the treatment were analyzed.Results There were 28 PD patients with RLS in total 102 PD patients and the incidence rate was 27.5%.All PD patients with RLS developed PD symptoms before RLS except one who had RLS symptoms prior to PD onset.HAMD score was significant statistical different between two groups （P〈0.05）.Other parameters including the general situation,the main symptoms,L-dopa treatment,Montreal and UPDRS score were not significant different between two groups （P〉0.05）.There was a negative correlation between age at onset of PD and the severity of RLS.Conclusions RLS in PD patients have a high incidence up to 27.5% and PD patients with RLS tend to develop depression.In PD patients with RLS,the younger onset,the more severe RLS is.