新生儿感染诊断指标的研究进展

The improvement of the diagnostic indicators for neonatal infectious diseases

随着免疫学、基因诊断学研究以及流式细胞技术的发展，新生儿感染性疾病的诊断有了许多新的进展。血清淀粉样蛋白A、干扰素．诱导蛋白．10、髓样细胞表达触发受体-1等对新生儿细菌感染的诊断有较高价值；细菌基因诊断等方面的研究可用于快速诊断新生儿脓毒症，增加基因芯片杂交方法还可明确菌种。由于每个诊断感染的指标均具有各自的临床及实验室特性，综合了解每一个感染指标的生物学特性、敏感度、特异度，连续并且联合监测几种指标可以提高诊断的敏感度和阴性预测值，是今后诊断感染性疾病的方向。

With the developing of the immunology, genetic diagnosis, and flow cytometry technology, the diagnosis of neonatal infectious diseases have been a lot of new improvement. Serum amyloid protein A, interferon-gamma-inducible protein 10 and triggering receptor expressed on myeloid cells-1 may be valuable in neonatal infectious diseases.Detection of the bacterial genes by gene chip hybridization technology can diagnose neonatal septicemia rapidly. Each of the diagnosis indicators for infection has their respective clinical and laboratory features. The comprehensive understanding of the biological characteristics,sensitivity,specificity of each indicator, and continuous and joint monitoring of several indicators can improve the diagnostic sensitivity and negative predictive value. It is the direction of infectious diseases diagnosis in future. This paper reviews the current diagnostic indicators for neonatal infectious disease.