5-HT3受体与肠易激综合征

5-HT3 receptors and irritable bowel syndrome

5-羟色胺（5-HT）及其受体广泛分布于胃肠道。5-HT3受体属于配体门控阳离子通道家族，现已分离5-HT3A、5-HT3B、5-HT3C、5-HT3D和5-HT3E 5种受体亚基。5-HT3受体基因型与肠易激综合征发病机制紧密联系，5-HT转运体基因型多态性影响肠易激综合征-D患者对5-HT3受体调节剂治疗效果。阿洛司琼、雷莫司琼为新一代选择性5-HT3受体拮抗剂，具有调节肠道动力及内脏感觉的药理作用，是治疗腹泻型肠易激综合征的有效药物；雷莫司琼和5-HT3受体具有更强的亲和力、更慢的解离速度和更强的拮抗活性。

Serotonin and its receptors exist extensively in gut,5-HT3 ieeeptor is ligand-gated ion channel. It is composed of five subunits,5-HT3A ,5-HT3B ,5-HT3c ,5-HT3D and 5-HT3E.The genetics of serotonin receptors appear to be associated with irritable bowel syndrome. 5-HTTLPR genetic polymorphisms influence the efficacy of serotonergie treatments. As a new generation of developed 5-HT3 receptor antagonists, alosetron and ramosetron act an important role in regulating gastrointestinal motility and visceral perception. They are efficacious in the treatment of irritable bowel syndrome. Ramosetron show high affinity for 5-HT3 receptors,dissociate slowly from 5-HT3 receptors and show long-lasting 5-HT3 receptor antagonism.