单核细胞趋化蛋白-1在口腔黏膜下纤维性变中的表达及意义

The expression of monocyte chemoattractant protein-1 in oral submucous fibrosis and Its clinical significace

目的:探讨单核细胞趋化蛋白-1(MCP-1)在口腔黏膜下纤维性变(OSF)组织中的表达及其意义。方法:应用免疫组织化学SP法检测45例OSF和15例正常口腔黏膜组织中MCP-1的表达及分布情况。结果:OSF组织中MCP-1的表达较正常组织增加,差异有统计学意义(P<0.01),MCP-1在OSF早期组织与中、晚期组织中的表达有显著性差异(P<0.05)。结论:MCP-1可能通过趋化、激活免疫和炎症细胞,在OSF发生发展中发挥重要作用。

Objective：To investigatet the expression and distribution of monocyte chemoattractant protein-1（MCP-1） in oral submucous fibrosis（OSF）and its role in the pathopoiesis of OSF.Method：The specific SP immunohistochemistry was used for detecting the expression and distribution of MCP-1 in tissues of 15 cases normal oral mucosa and 45 cases OSF.Result：A slight positive expression of MCP-1 protein was detected in normal oral mucosa,and a significant increasing of expression could be found in every stage OSF（P〈0.01）.Compared with intermediate and advanced stages,the expression of MCP-1 of early stage OSF was highest（P 〈0.05）.Conclusion：MCP-1 might play vital roles in the pathopoiesis of OSF.