针刺对心肌缺血再灌注中心肌保护的现代研究

Progress of Researches on the Protectue Effect of Acupucture in Resisting Myocardial Ischemia-reperfusion Injury

心肌缺血再灌注对心肌损伤主要是通过氧自由基生成增多、Ca2+超载、血管内皮细胞功能障碍、中性粒细胞激活、心肌细胞凋亡等多种机制相互作用产生,本文就上述方面对近10年来针刺修复心肌缺血再灌注损伤的机制进行了综述,发现针刺对心肌缺血再灌注损伤的修复作用机制研究日趋深入,但研究以动物实验为主,因此认为今后的研究重点应集中于临床研究。

In the present paper, the authors review progresses of researches on the protective effect of acupuncture in resisting acute myocardial ischemia-reperfusion injury in patients and animals from 1） resisting injury of oxygen-derived free radicals,2） reducing intracellular Ca^2＋ overload, 3） relieving dysfunction of vascular endothelial cells of the myocardium, 4） regulating immune functional activity and reducing inflammatory injury, 5） reducing cardiocyte apoptosis, 6） upregulating the expression of heat shock protein （HSP 70） in the myocardium, and 7） regulating activities of multiple cardiovascular protection factors and intracellular signaling pathways. The abovementioned results are mainly obtained from experimental animal studies. For this reason, the authors hold that the coming researches on acupuncture therapy for cardiovascular disorders should pay more attention to its clinical application, for example, controlled blood-pressure decline induced lower perfusion of the coronary artery, cardiac surger- y （percutanecus tranluminal coronary angioplasty, intracardiac operation underdirect vision） etc.