内质网应激与肝损伤研究进展

Role of endoplasmic reticulum stress in hepatocytes in the pathogenesis of liver injury

肝脏疾病组织学损伤,在细胞水平上可分为坏死和凋亡.近年来,大量研究表明,应激可能是肝损伤发生过程中的重要环节,如内质网应激、线粒体应激和氧化应激等,其中内质网应激是医学研究的一个新热点.本文将以内质网应激为切入点,探讨内质网应激的作用功能,内质网应激对细胞凋亡的影响,以及内质网应激与各种肝损伤之间的关系并对之进行综述.

The necrosis and apoptosis of hepatocytes play an important role in the pathogenesis of liver injury.In recent years,numerous studies have shown that hepatocyte stress,such as endoplasmic reticulum stress,mitochondrial stress and oxidative stress,may occur in the process of liver injury.The research on endoplasmic reticulum stress has become a new hot topic.This paper will review the role of endoplasmic reticulum stress in hepatocytes in the pathogenesis of a variety of liver injuries.