甘草粗提物及其黄酮类成分的抗肿瘤作用

Anticancer activities of crude extracts of licorice and its flavonoids

甘草中的黄酮类成分是广谱抗肿瘤活性成分,已发现异甘草素、异甘草苷、甘草查耳酮A、甘草查耳酮E、甘草素、光甘草定、光甘草素和甘草醇等8个黄酮类成分具有抗肿瘤作用,其中对异甘草素抗肿瘤作用的研究最为广泛和深入,可望将其开发成低毒抗癌药。综述了甘草粗提物、甘草黄酮类化合物的抗肿瘤作用。

Flavonoid constituents from licorice have broad-spectrum anticancer activities. There are eight kinds of flavonoid compounds with anticancer activities, including isoliquiritigenin, isoliquiritin, licochalcone A, licochalcone E, liquiritigenin, glabridin, glabrene and glycyrol. Among the compounds, isoliquiritigenin is the one that has been deep and widely studied, which show that it is promising to become a hypotoxic anticancer drug. This review summarize the anticancer effects of crude extracts licorice and its flavonoids.