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TCF7L2基因和2型糖尿病发病机制的研究进展

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作者 曹永红 戴武
机构地区 合肥市第二人民医院内分泌科
出处 《临床荟萃》 CAS 2010年第11期1010-1012,共3页 Clinical Focus
基金 合肥市科技局重点立项项目[合科合同(卫)字2008(1014)号]
关键词 糖尿病 2型 基因 细胞凋亡 胰岛素抗体
分类号 R578.1 [医药卫生—消化系统]
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参考文献24

  • 1Grant SF, Thorleifsson G, Reynisdottir I, et al. Variant of transcription factor 7-like 2(TCF7L2) gene confers risk of type 2 diabetes[J]. Nat Genet, 2006,38(3): 320-323.
  • 2Groves CJ, Zeggini E, Minton J, et al. Association analysis of 6, 736 U. K. subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk[J]. Diabetes, 2006,55 (9) : 2640-2644.
  • 3Parra EJ, Cameron E, Simmonds L, et al. Association of TCFTL2 polymorphisms with type 2 diabetes in Mexico City [J]. Clin Genet,2007,71(4) :359-366.
  • 4Lyssenko V, Lupi R, Marchetti P, et al. Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes[J]. J Clin Invest, 2007,117(8) : 2155-2163.
  • 5Scott LJ, Bonnycastle LL, Wilier CJ, et al. Association of transcription factor 7-like 2 (TCF7L2) variants with type 2 diabetes in a finnish sample[J]. Diabetes, 2006,55 (9) : 2649- 2653.
  • 6Weedon MN, McCarthy MI, Hitman G, et al. Combining information from common type 2 diabetes risk polymorphisms improves disease prediction[J]. PLoS Med, 2006,3 (10) : e374.
  • 7Ng MC, Tam CH, Lain VK, et al. Replication and identification of novel variants at TCFTL2 association with type 2 diabetes in Hong Kong Chinese[J]. J Chin Endocrinol Metab, 2007, 92 (9) : 3733-3737.
  • 8Chang YC,Chang TJ ,Jiang YD,et al. Association study of the genetic polymorphisms of the transcription factor 7-like 2 (TCFTL2) gene and type 2 diabetes in the Chinese population [J]. Diabetes, 2007,56 (10) : 2631-2637.
  • 9Sladek R, Rocheleau G, Rung J, et al. A genome-wide association study identifies novel risk loci for type 2 diabetes [J]. Nature,2007,445(7130):881-885.
  • 10杨文英.新一代药物GLP-1类似物对2型糖尿病患者β细胞功能的保护[J].中华内分泌代谢杂志,2008,24(6). 被引量：11

二级参考文献75

  • 1Wild S, Roglic G, Green A, et al. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care, 2004,27 : 1047-1053.
  • 2Kahn SE, Hull RL, Utzschneider KM. Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature, 2006,444:840-846.
  • 3Weir GC, Bonner-Weir S. A dominant role for glucose in beta cell compensation of insulin resistance. J Clin Invest, 2007,117 : 81-83.
  • 4Terauchi Y, Takamoto I, Kubota Net al. Glucokinase and IRS-2 are required for compensatory beta cell hyperplasia in response to high-fat diet-induced insulin resistance. J Clin Invest, 2007,117:246-257.
  • 5Butler AE, Janson J, Bonner-Weir S, et al. Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes, 2003,52 : 102-110.
  • 6Kloppel G, Lohr M, Habich K, et al. Islet pathology and the pathogenesis of type 1 and type 2 diabetes mellitus revisited. Surv Synth Pathol Res, 1985,4 : 110-125.
  • 7de-Koning EJ, Bodkin NL, Hansen BC, et al. Diabetes mellitus in Macaca mulatta monkeys is characterised by islet amyloidosis and reduction in beta-cell population. Diabetologia, 1993,36:378-384.
  • 8Yoon KH, Ko SH, Cho JH, et al. Selective β-cell loss and α-cell expansion in patients with type 2 diabetes mellitus in Korea. J Clin Endocrinol Metab, 2003,88:2300-2308.
  • 9Sakuraba H, Mizukami H, Yagihashi N, et al. Reduced beta-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese type Ⅱ diabetic patients. Diabetologia, 2002,45:85-96.
  • 10Del-Prato S, Wishner WJ, Gromada J, et al. Beta-cell mass plasticity in type 2 diabetes. Diabetes Obes Metab, 2004,6:319-331.

共引文献27

临床荟萃
2010年 第11期

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