D-对羟基苯甘氨酸合成的研究进展

PROGRESS IN SYNTHESIS OF D-p-HYDROXYPHENYLGLYCINE

分别介绍了生物酶催化和化学合成D-对羟基苯甘氨酸的方法,生物酶催化法的选择性高,污染小,反应条件温和,是未来发展的方向。其关键是酶的固载与循环使用。化学合成法有对甲氧基苯甲醛法、Strecker氨基酸合成法以及醛酸-苯酚法3种,其中醛酸-苯酚法工艺成熟,是目前工业上普遍采用的方法,但对环境有一定污染。同时还讨论了D,L-对羟基苯甘氨酸的拆分方法。

Herein, the enzymetic and chemical methods for the synthesis of D-p-hydroxyphenylglycine are introduced respectively. It is concluded that enzymetic method has the properties of high selectivity, low pollution, and mild reaction conditions and will be adopted in the future. The key problem is how to immobilize the enzyme to make it reusable. There are three chemical methods, so called p-methoxy benzaldehyde method, Strecker method and glyoxalic acid-phenol method, for the synthesis of D-p-hydroxyphenylglycine. Among of the three methods, glyoxalic acid-phenol method is developed fully and adopted in industry today. However, the method has high pollution on the environment. The resolution of D,L-p-hydroxyphenylglycine to get the D-enantiomer is also discussed.