血清尿酸水平与冠状动脉病变程度的关系

Relationship between Serum Uric Acid Level and Severity of Angiographic Coronary Artery Disease

目的:探讨冠状动脉造影患者血清尿酸(SUA)水平与冠状动脉病变程度的关系。方法:入选我院行冠状动脉造影(CAG)患者474例,根据CAG结果分为冠心病(CAD)组(366例)和非CAD组(108例)。冠状动脉病变程度采用冠状动脉病变支数和冠状动脉病变Gensini积分(GS)量化。结果:(1)总体CAD组SUA水平高于非CAD组(P<0.05),亚组分析女性CAD组SUA水平高于女性非CAD组(P<0.05);总体CAD组、男性CAD组、女性CAD组高尿酸(HUA)百分比均高于非CAD组(P<0.05)。(2)SUA水平第3、第4四分位的CAD患病率明显高于第1、第2四分位(P<0.05)。(3)多因素Logistic回归分析显示HUA是经CAG诊断的CAD的危险因素(OR=2.639,95%CI为1.080～6.443,P=0.033)。(4)相关分析提示SUA水平和GS有正相关性(r=0.270,P<0.01),亚组分析男性、女性SUA水平和GS间均有正相关性(r=0.171,P<0.01;r=0.298,P<0.01)。结论:SUA可能是CAG诊断的CAD的危险因素。SUA水平和冠状动脉病变程度有一定相关性,女性相关性较男性略显著。

Objective：To evaluate the relationship between the serum uric acid （SUA） level and the severity of angiographic coronary artery disease （CAD）.Methods：Four hundred and seventy-four consecutive patients underwent coronary angiography were selected according to the inclusion criteria.Of them,366 cases were diagnosed as CAD and 108 cases were Non-CAD.The severity of angiographic CAD was assessed by the number of diseased vessels and Gensini score.Results：1.The SUA level was higher in CAD patients than that of Non-CAD patients （P 0.05）.The SUA level was higher in female CAD patients than that of female Non-CAD patients （P 0.05）.The percentage of hyperuricemia （HUA） was significantly higher in CAD patients than that in Non-CAD patients （P 0.05）.The same results were found in male and female CAD patients （P 0.05）.2.A significantly higher percentage of CAD patients was found in SUA levels in the range of quartile 3 and 4 than that of SUA levels of quartile 1 and 2 （P 0.05）.3.Logistic regression analysis showed that HUA was an independent risk factor of CAD （OR = 2.639,95%CI： 1.080-6.443,P=0.033）.4.Significant correlations were found between the SUA level and Gensini score （r = 0.270,P 0.01）.The same results were found in different genders （men： r = 0.171,P 0.01;women： r = 0.298,P 0.01）.Conclusion： The high serum uric acid concentration could be a risk factor for coronary artery disease.The serum uric acid level was correlated with the severity of CAD.The relationship trends to be a little stronger in women than that in men.