摘要
在电镜下观察了加味温胆汤对D-半乳糖亚急性衰老大鼠大脑皮质神经元超微结构改变的影响,并对其主要细胞器进行了计量分析。结果表明:模型组脂褐素数量较正常组增多(P<0.05),线粒体则减少(P<0.05)同时还发现溶酶体、脂褐素大小形态不规则,线粒体肿胀、变性、嵴断裂、空泡样变,核膜内褶断裂,核仁边移等衰老改变,而加味温胆汤则使上述变性程度减轻,从而表明该方能延缓脑衰老,并提示该方可能具有稳定神经细胞生物膜系统作用。
The influence of supplemented gallbladder-warming decoction on cerebral cortex ultrastuctuer of subacute senile rats was observed and analised.The results showed that in model group,lipofuscin was increased(P<0 05),mitochondriona was decreased(P<0 05),the size of lipofuscin was irregular,mitochondrion was turgescent,nuclear membrane was broken and nucleolus was marginated.Supplemented gallbladder-warming decoction could slow the above changes.It suggested that supplemented gallbladder-warming decoction could delay the senility of brain and stabilize the system of nerve ecell biomembrane.
出处
《湖南中医学院学报》
1999年第1期8-9,共2页
Journal of Hunan College of Traditional Chinese Medicine
基金
湖南省卫生厅中医管理局资助
关键词
温胆汤
大脑皮质
神经元
超微结构
抗衰老
Gallbladder-warming Decoction
senility
cerebral cortex ultrastructure
rats(page 16)