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加味温胆汤对亚急性衰老大鼠大脑皮质超微结构改变的影响 被引量:16

INFLUENCE OF SUPPLEMENTED GALLBLADDER-WARMING DECOCTION ON CEREBRAL CORTEX ULTRASTRUCTUER OF SUBACUTE SENILE RATS
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摘要 在电镜下观察了加味温胆汤对D-半乳糖亚急性衰老大鼠大脑皮质神经元超微结构改变的影响,并对其主要细胞器进行了计量分析。结果表明:模型组脂褐素数量较正常组增多(P<0.05),线粒体则减少(P<0.05)同时还发现溶酶体、脂褐素大小形态不规则,线粒体肿胀、变性、嵴断裂、空泡样变,核膜内褶断裂,核仁边移等衰老改变,而加味温胆汤则使上述变性程度减轻,从而表明该方能延缓脑衰老,并提示该方可能具有稳定神经细胞生物膜系统作用。 The influence of supplemented gallbladder-warming decoction on cerebral cortex ultrastuctuer of subacute senile rats was observed and analised.The results showed that in model group,lipofuscin was increased(P<0 05),mitochondriona was decreased(P<0 05),the size of lipofuscin was irregular,mitochondrion was turgescent,nuclear membrane was broken and nucleolus was marginated.Supplemented gallbladder-warming decoction could slow the above changes.It suggested that supplemented gallbladder-warming decoction could delay the senility of brain and stabilize the system of nerve ecell biomembrane.
出处 《湖南中医学院学报》 1999年第1期8-9,共2页 Journal of Hunan College of Traditional Chinese Medicine
基金 湖南省卫生厅中医管理局资助
关键词 温胆汤 大脑皮质 神经元 超微结构 抗衰老 Gallbladder-warming Decoction senility cerebral cortex ultrastructure rats(page 16)
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  • 1Zhang C F,FEBS Lett,1992年,297卷,1/2期,34页
  • 2Wei Y H,Mutat Res,1992年,515卷,145页
  • 3张鑫生,青海医药杂志,1991年,1期,51页

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