摘要
目的探讨强迫症与5-羟色胺(5-HT)的关系。方法本文选用氯丙咪嗪和氟西汀治疗38名强迫症病人,同时观察治疗前后患者血小板5-HT含量的变化。结果未服药强迫症病人血小板5-HT含量较正常人高(P<0.01)。经药物治疗后,患者的强迫症状明显好转、血小板5-HT含量逐渐下降,且治疗后血小板5-HT含量与Y-BOCS评分下降百分率呈负相关(r=-0.6204,P<001)。结论提示强迫症发病可能与5-HT异常有关。
Objective The
purpose of this study was to research the relationship between obsessive-compulsive
disordor(OCD) and 5-hydroxtryptamine(5-HT). Methods 38 cases of OCD were treated with
serotonin reuptake inhibitors,either climipramine or fluoxetine. Platelet 5-HT content of the
patients were observed before and after treatment. Results It was found that the drug-free OCD
patients had a higher level of platelet 5-HT content than that of the normal ( P< 0.01).There
were graduate improvement of their OCD symptoms and reduction of platelet 5-HT content of
obsessive-compulsive patients after six weeks treatment with clomipramine or
fluoxetine.Moreover,the platelet 5-HT concentration after treatment was negatively correlated
with percentages of Yale-Brown obsessive-compulsive scales(Y-BOCS) reduction(
r=-0.6204,P< 0.01). Conclusions These results suggest that OCD might have 5-HT dysfunction.
出处
《中国神经精神疾病杂志》
CAS
CSCD
北大核心
1999年第2期65-67,共3页
Chinese Journal of Nervous and Mental Diseases
关键词
强迫症
羟色胺
氯丙秦
氟西汀
疗效
药物疗法
Obsessive-compulsive Disorder serotonin Clomipramine Fluoxetine Efficacy