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氯丙咪嗪及氟西汀治疗强迫症疗效与5-羟色胺含量的动态观察 被引量:10

A study on dynamic change of efficacy and platelet serotonin content during clomipramine and fluoxetine treatment of obsessive-compulsive disorder.
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摘要 目的探讨强迫症与5-羟色胺(5-HT)的关系。方法本文选用氯丙咪嗪和氟西汀治疗38名强迫症病人,同时观察治疗前后患者血小板5-HT含量的变化。结果未服药强迫症病人血小板5-HT含量较正常人高(P<0.01)。经药物治疗后,患者的强迫症状明显好转、血小板5-HT含量逐渐下降,且治疗后血小板5-HT含量与Y-BOCS评分下降百分率呈负相关(r=-0.6204,P<001)。结论提示强迫症发病可能与5-HT异常有关。 Objective The purpose of this study was to research the relationship between obsessive-compulsive disordor(OCD) and 5-hydroxtryptamine(5-HT). Methods 38 cases of OCD were treated with serotonin reuptake inhibitors,either climipramine or fluoxetine. Platelet 5-HT content of the patients were observed before and after treatment. Results It was found that the drug-free OCD patients had a higher level of platelet 5-HT content than that of the normal ( P< 0.01).There were graduate improvement of their OCD symptoms and reduction of platelet 5-HT content of obsessive-compulsive patients after six weeks treatment with clomipramine or fluoxetine.Moreover,the platelet 5-HT concentration after treatment was negatively correlated with percentages of Yale-Brown obsessive-compulsive scales(Y-BOCS) reduction( r=-0.6204,P< 0.01). Conclusions These results suggest that OCD might have 5-HT dysfunction.
出处 《中国神经精神疾病杂志》 CAS CSCD 北大核心 1999年第2期65-67,共3页 Chinese Journal of Nervous and Mental Diseases
关键词 强迫症 羟色胺 氯丙秦 氟西汀 疗效 药物疗法 Obsessive-compulsive Disorder serotonin Clomipramine Fluoxetine Efficacy
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  • 1万海英,江苏医药,1985年,11卷,12期,24页

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