慢性乙肝患者生活质量量表的编制

Development of a Quality of Life Scale for Patients with Chronic Hepatitis B

目的:编制适用于我国慢性乙肝患者的特异性生活质量量表(QLS-CHB)。方法:采用结构化的决策方法编制条目,对227名患者进行调查后,以反应度分析、相关分析法及因素分析法筛选条目,并对量表进行信、效度的检验。结果:探索性因素分析抽取的四个因子与理论构想的疾病、生理、心理和社会四个维度相符,共解释了总方差的49.635%。条目与各维度的相关为0.531-0.814,各维度与总分的相关为0.697-0.869。QLS-CHB与SF-36总分的相关系数为0.775。总量表的Cronbach’sα系数为0.941,各维度的Cronbach’sα系数为0.775-0.914。总量表的重测相关系数为0.925,各维度的重测相关系数为0.675-0.886。结论:QLS-CHB有良好的信效度。

Objective： To develop a quality of life scale for patients with chronic hepatitis B（QLS-CHB） applicable to our country.Methods： The scale was developed with the programmed decision methods.Three methods were used in item selection,after the study that 227 CHB patients were recruited.Then the reliability and validity of the scale was assessed.Results： Four dimensions including disease,physiology,psychology and society were extracted through exploratory factor analysis,which were consistent with the theoretical concepts.They explained 49.635% of the total variance.The correlation between items and subscales was 0.531-0.814,and the correlation between the four dimensions and total scale was 0.697-0.869.The correlation of total scores between QLS-CHB and SF-36 was 0.775.The total Cronbach’ α was 0.941,the Cronbach’ α of per dimension was 0.775-0.914.The test-retest reliability of the whole scale was 0.925,and the test-retest reliability of per subscale was 0.886-0.964.Conclusion： The reliability and validity of QLS-CHB have reached the acceptable level in psychometrics and can be used in assessing the quality of life of patients with chronic hepatitis B.