摘要
目的研究石榴花提取物(Pomegranate Flower Extract,PFE)对2型糖尿病伴高血脂大鼠血糖、血脂以及肝脏组织形态结构的影响。方法通过腹腔注射链脲佐菌素(STZ)45 mg/kg,加高脂饲料喂养建立糖尿病脂代谢紊乱大鼠模型,将成模大鼠随机分为模型组和两个给药剂量组,另设正常对照组,在接受石榴花提取物治疗4周后,测定其有关生化指标及肝脏组织检查。结果与模型组比较,石榴花提取物组2型糖尿病伴高血脂大鼠的空腹胰岛素(FINS)、空腹血糖(FPG)、胰岛素抵抗指数,降低总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C),升高高密度脂蛋白胆固醇占总胆固醇之比(HDL-C/TC)显著降低;肝脏病理显示:与模型组相比,治疗组大鼠肝小叶结构清晰,肝细胞脂肪变性明显减少,肝细胞排列基本规则。结论石榴花提取物对2型糖尿病伴高血脂大鼠的糖脂代谢具有一定的调节作用,对肝脏有一定的保护作用。
Objective To study the protective effect of pomegranate flower extract (PFE) on rats of STZ- induced diabetes. Methods Model group was established with STZ. Model group were treated with PFE for weeks. The fasting plasma glucose (FPG), fasting insulin (Fins), in sulin resistance index (ISI) and liver structure were detected. Results The rats of model group showed decreased FPG, Fins, ISI, total cholesterol (TC) and LDL-C and increased HDL-C/ TC. Architecture of rat livers in model group showed decreased adipose degeneration. Conclusion The results suggests that PFE could be used to impair glu- cose and lipid metabolism and protect liver of DM rats.
出处
《新疆医科大学学报》
CAS
2010年第4期379-382,共4页
Journal of Xinjiang Medical University
基金
新疆维吾尔自治区科技攻关(含重大专项)和重点项目计划(200733146)
关键词
2型糖尿病
血糖
血脂
肝脏病理
石榴花
type 2 diabetes mellitus
fasting plasma glucose (FPG)
plasma lipid
liver structure
pome- granate flower extract