摘要
目的通过石榴花提取物(Pomegranate Flower Extract,PFE)对2型糖尿病(T2DM)大鼠空腹血糖(FPG)、血清胰岛素、炎症因子白介素-6(IL-6)和胸腺指数的影响,研究PFE对糖尿病大鼠免疫功能的影响。方法采用高热量饲料加小剂量链脲佐菌素建立实验性2型糖尿病大鼠模型,分别用石榴花提取物100 mg/kg和300 mg/kg治疗4周后,处死大鼠,测定空腹血糖(FPG)和血清胰岛素水平(INS),白介素-6(IL-6)的含量,计算胸腺指数、胰岛素敏感性指数(ISI),推断对T2DM大鼠免疫功能的影响。结果石榴花提取物能显著降低2型糖尿病大鼠的空腹血糖,显著增加ISI。降低血清炎症因子IL-6并提高胸腺指数。结论石榴花提取物可降低2型糖尿病大鼠的空腹血糖,降低血清炎症因子IL-6的含量并提高胸腺指数。
Objective To study the protective effect of pomegranate flower extracts(PFE) on rats with STZ-induced type 2 diabetes mellitus.Methods Rats with STZ-induced type 2 diabetes were established with high calorie feeding and small dose injection of STZ,then treated with PFE for 4 weeks.The FPG,ISI,thymus index and IL-6 were detected.Result: Oral administration of PFG at doses of 100 mg/kg and 300 mg/kg for 28 days resulted in a significant reduction in FPG and IL-6,coupled with elevation of ISI and thymus index in comparison with diabetic control group.Conclusion The results suggest that PFE could be used in the treatment of inflammation of T2DM.
出处
《新疆医科大学学报》
CAS
2010年第5期496-498,共3页
Journal of Xinjiang Medical University
基金
新疆维吾尔自治区科技攻关(含重大专项)和重点项目计划(200733146)
关键词
石榴花提取物
2型糖尿病
胰岛素
IL-6
胸腺指数
pomegranate flower extract(PFE)
type 2 diabetes mellitus
insulin
interleukin-6(IL-6)
thymus index