核转录因子κB和血管内皮生长因子在视网膜母细胞瘤中的表达及意义

Expression of nuclear factor κB and vascular endothelial growth factor in retinoblastoma and its clinical significance

目的:探讨核转录因子(nuclear factor κB,NF-κB)和血管内皮生长因子(vascular endothelial growth factor,VEGF)在视网膜母细胞瘤(retinoblastoma,RB)中的表达及其与RB分化程度和视神经浸润的关系。方法:采用免疫组织化学方法检测33例RB常规石蜡包埋标本的NF-κB和VEGF表达,统计分析NF-κB和VEGF与RB分化及浸润的关系。结果:NF-κB和VEGF在RB组织细胞中的表达均明显高于正常视网膜中的表达(P<0.01),且均与RB分化程度相关(P=0.027)。VEGF在RB视神经浸润组与未浸润组的表达差异也有统计学意义(P=0.033)。结论:NF-κB和VEGF均参与RB的形成,且VEGF可能与RB的浸润有关。

Objective：To investigate the expression of nuclear factor κB（NF-κb）and vascular endothelial growth factor（VEGF）in retinoblastoma（RB）,and its relationship with the differentiation and optic nerve infiltration.Methods：The expression of NF-κB and VEGF was examined in 33 cases of RB tissue using immunohistochemistry.The relationship between the differentiation and invasion among NF-κB,VEGF and RB was analyzed statistically.Results：The expression of RB in NF-κB and VEGF was obviously higher than that in normal retina（P0.01）,and the expression was related to the differentiation degree of RB（P=0.027）.The expression of VEGF was significantly different between invasive and non-invasive optic nerves of RB（P=0.033）.Conclusions：NF-κB and VEGF are both involved in the formation of RB,and VEGF may be associated with the invasion of RB.