期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

Kisspeptin/GPR54系统与青春期启动的研究进展 被引量：1

The research between Kisspeptin/GPR54 system and the initiating of puberty
下载PDF
导出
摘要 Kisspeptin是由转移抑制基因kiss-1编码的肽类物质,并且kisspeptin是G蛋白偶联受体54(GPR54)天然配体。Kisspeptin/GPR54系统与青春期的启动关系密切。kiss-1可能通过促性腺激素释放激素(gonadotropin releasing hormones,GnRH)神经元诱发体内黄体化激素的分泌从而参与青春期的启动。 Kisspeptin is a kind of peptides which is encoded by kiss-1 and is the natural ligand of GPR54.The relationship between kisspeptin/GPR54 system and the initiating of puberty is very close.It is probably that kiss-1 participate in the activity of puberty through inducing LH release by GnRH neuron.
作者 张春东 刘畅 翟玲玲
机构地区 中国医科大学临床医学系 中国医科大学公共卫生学院
出处 《中国当代医药》 2010年第17期17-18,共2页 China Modern Medicine
基金 国家自然科学基金资助项目(30800920)
关键词 KISSPEPTIN G蛋白偶联受体54 青春期启动 下丘脑 促性腺激素释放激素 Kisspeptin GPR54 Initiating of puberty Hypothalamus Gonadotropin releasing hormones
分类号 R338 [医药卫生—人体生理学]
  • 相关文献

参考文献13

  • 1Dungan HM,Gottsch ML,Zeng H,et al.The role of kisspeptin-GPR54 signaling in the tonic regulation and surge release of gonadotropin-releasing hormone/luteinizing hormone[J].The Journal of Neuroscience,2007,27(44):12088-12095.
  • 2de Roux N,Genin E,Carel JC,et al.Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54[J].Proc Natl Acad Sci USA,2003,100(19):10972-10976.
  • 3Levine JE.Gonadotropin-releasing hormone (GnRH)[M] //Henry H,Norman A.Encyclopedia of hormones,San Diego:Academic Press,2003:157-165.
  • 4Ojeda SR,Urbanski HF.Puberty in the rat[J].The physiology of reproduction,2005,2:363 -407.
  • 5Popa SM,Clifton DK,Steiner RA.A Kiss to remember[J].Trends Endocrinol Metab,2005,16(6):249-250.
  • 6Parhar IS,Ogawa S,Sakuma Y.Laser captured single digoxigenin-labeled neurons of gonadotrop in-releasing hormone types reveal a novel G protein-coupled receptor (GPR54) during maturation in cichlid fish[J].Endocrinol,2004,145(8):3613-3618.
  • 7Aro VM,Castellano JM,Garcia-Galiano D,et al.Neuroendocrine factors in the initiation of puberty:The emergent role of kisspeptin[J].Rev Endocr Metab Disord,2007,8(1):11-20.
  • 8Funes S,Hedrick JA,Vassileva G,et al.The Kiss-1 receptor GPR54 is essential for the development of the murine reproductive system[J].Biochemical Biophys Res Commun,2003,312(4):1357-1363.
  • 9Seong-Kyu Han,Michelle L,Gottsch,et al.Activation of GonadotropinReleasing Hormone Neurons by Kisspeptin as a Neuroendocrine Switch for the Onset of Puberty[J].The Journal of Neuroscience,2005,25(49):11349-11356.
  • 10Messager S,Chatzidaki EF,Ma D,et al.Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54[J].Proc Nail Acad Sci USA,2005,102(5):1761-1766.

二级参考文献35

  • 1Lee DK, Nguyen T, O'Neill GP, et al. Discovery of a receptor related to the galanin receptors[J]. FEBS Letters,1999,446(1): 103-107.
  • 2Muir MI, Chamberlain L, Elshourbagy NA, et al. AXOR12,a novel human G protein-coupled receptor, activated by the peptide Kiss-1[J]. J Biol Chem, 2001,276(31): 28969-28974.
  • 3Lee JH, Miele ME, Hicks DJ, et al. Kiss-1,a noval human malignant melanoma metastasis-suppressor gene[J].J Natl Cancer Inst,1996,88 (23):1731-1737.
  • 4Lee JH, Welch DR. Suppression of metastasis in human breast carci- noma MDA-MB- 435 cells after transfection with the metastasis suppressor gene, KiSS -1[J]. Cancer Res, 1997, 57(12):2384-2387.
  • 5West A, Vojta PJ, Welch DR, et al. Chromosome localization and genomic structure of the Kiss-1 metastasis suppressor gene(Kiss1)[J].Genomics,1998,54(1):145-148.
  • 6Othtaki T, Shitani Y, Honda S, et al. Metastasis suppressor gene Kiss-1 encodes peptide ligand of a G protein-coupled receptor[J]. Nature,2001, 411(6837):613-617.
  • 7Kotani M, Detheax M, Vandenbogaerde A, et al. The metastasis suppressor gene Kiss-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54[J]. J Biol Chem, 2001, 276(37):34631-34636.
  • 8Stafford LJ, Xia C, Ma W, et al. Identification and characterization of mouse metastasis-suppressor KiSSI and its G-protein coupled receptor [J]. Cancer Res, 2002, 62 (19):5399-5404.
  • 9Nararro VM, Castellano JM, Fernandez R, et al. Developmental and hormonally regulated messenger ribonucleic acid expression of Kiss-1 and its putative receptor GPR54 in rat hypothalamus and potent LH releasing activity of Kiss-1 peptide[J]. Endocrinol, 2004,145(10):4567-4574.
  • 10Nararro VM, Castellano JM, Fernandez R, et al. Characterization of the potent LH releasing activity of Kiss-1 peptide, the natural ligand of GPR54[J]. Endocrinol,2005,146(1):1156-1163.

共引文献3

同被引文献10

引证文献1

二级引证文献4

中国当代医药
2010年 第17期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部