D-二聚体在膀胱肿瘤诊断中的应用及手术影响

The application of D-dimer in the diagnosis of bladder cancer and the surgical influence on its level

目的探讨D-二聚体含量在膀胱肿瘤诊断中的应用及手术创伤对其含量的影响。方法通过定量酶联免疫吸附试验对43例膀胱移行细胞癌患者行D-二聚体测定。结果肿瘤患者血浆D-二聚体含量较非肿瘤患者及正常组明显增高（P＜0.01），水后膀胱肿瘤患者及非肿瘤患者血浆D-二聚体含量较术前明显增高（P＜0.01），肿瘤患者高于非肿瘤患者（P＜0.01）。结论膀胱肿瘤患者体内处于继发性纤溶活性增高状态。手术创伤可增强肿瘤患者和非肿瘤患者血浆纤溶活性增高状态。

Objective To assess the role of D-dimer in the diagnosis of bladder cancer and the surgical influence on its level. Method Using quantitative enzyme-linked immunosorbent assay (ELISA), D-dimer level was determined in 43 patients with transitional cell carcinoma of bladder (TCC) and 62 with urinary benign diseases as well as 40 normal controls. Result The mean plasma level of D-dimer in the patients with bladder cancer was much higher than in urinary benign diseases and normal controls (P < 0.01 ). Postoperative plasma level of D-dimer was significantly increased in the patients with bladder cancer and urinary benign diseases as compared with preoperative level (P < 0. 01 ), and the level in cancer patients was obviously higher than in urinary benign diseases (P < 0. 01 ). Conclusion The fibrinolysis has occurred in the patients with bladder cancer. The operative trauma could enhance the fibrinolysis in the patients with bladder cancer or urinary benign disease.