摘要
内质网应激介导的细胞凋亡是一种新的凋亡途径,不同于死亡受体信号途径和线粒体途径。短期的内质网应激有保护细胞的作用,但是长期的内质网应激将激活一些凋亡信号分子如CHOP、JNK、Caspase,而诱导细胞凋亡。
Apoptosis mediated by endoplasmic reticulum stress is a new apoptosis pathway,which is different from the death receptor signaling pathway and mitochondrial pathway.The short-term endoplasmic reticulum stress can protect cells,while long-term endoplasmic reticulum stress induce cell apoptosis by activating some apoptotic signal molecules such as C/EBP homologous protein（CHOP）,JNK（c-Jun amino-terminal kinase）,caspase.
出处
《药学与临床研究》
2010年第3期291-293,298,共4页
Pharmaceutical and Clinical Research
关键词
内质网应激
未折叠蛋白反应
细胞凋亡
Endoplasmic reticulum stress
Unfolded protein response
Apoptosis
