载气流速对高场不对称波形离子迁移谱的影响

Effect of Carrier Gas Flow Rate on High-Field Asymmetric Waveform Ion Mobility Spectrometry

载气流速是影响高场不对称波形离子迁移谱(FAIMS)的重要参数。以自制的高场不对称波形离子迁移谱仪为实验平台,在射频电场幅值3kV/cm,频率500kHz,占空比0.36的条件下,研究了载气流速对苯离子迁移谱谱峰强度和半峰宽的影响。实验结果表明:载气流速为3.7L/min时,苯样品的谱峰强度最大,仪器的灵敏度最高。随着载气流速的增加,谱峰半峰宽变宽,仪器的分辨率下降。载气流速为3.0～3.7L/min时仪器综合性能最佳。此结果对于控制迁移谱仪载气流速有重要的参考意义。

Carrier gas flow rate is a key parameter that significantly affects the high-field asymmetric waveform ion mobility spectrometry.The effect of carrier gas flow rate on the benzene spectral peak intensity and peak width at half maximum has been investigated on the homemade high-field asymmetric waveform ion mobility spectrometer under the conditions of radio frequency electric field magnitude 30000 V/cm,frequency 500 kHz and dutyfactor 0.36.The experiment results showed that the flow rate at 3.67 L/min provides the maximum peak intensity and optimal sensitivity.The peak width at half maximum broadens and the resolving power decreased with the increase of carrier gas flow rate.The optimal spectrometer performance was obtained at the flow rates between 3 L/min and 3.67 L/h.The results and conclusions are useful for the carrier gas flow rate optimal control of high-field asymmetric waveform ion mobility spectrometry.