摘要
目的:探讨不同甲状腺功能的绝经前女性血清饥饿素(ghrelin)水平与其身体成份骨量(BMC)、脂肪量(FM)、肌肉量(LM)的相互关系。方法:采用放射免疫分析法检测71例不同甲状腺功能的绝经前女性其中包括甲状腺机能亢进(甲亢)组33例、甲状腺机能减低(甲减)组18例、正常对照组20例的血清饥饿素水平,同时采用化学发光快速检测法检测其血清游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、灵敏促甲状腺激素(sTSH);并采用双能X线吸收法(DXA)测定其全身身体成份(骨量、脂肪量、肌肉量),同时记录体重(BW)。结果:(1)甲亢组血清饥饿素水平明显低于正常对照组(P<0.01)和甲减组(P<0.01),甲减组血清饥饿素水平与正常对照组之间无显著差别(P>0.05)。血清饥饿素与其FT3(r=-0.318,P<0.01)、FT4(r=-0.350,P<0.01)呈负相关,与sTSH(r=0.281,P<0.05)呈正相关。(2)血清饥饿素与全身骨量(r=0.284,P<0.05)、肌肉量(r=0.259,P<0.05)、体重(r=0.279,P<0.05)存在正相关;与脂肪量不存在相关(P>0.05)。结论:不同甲状腺功能的绝经前女性血清饥饿素可能影响其全身骨量、肌肉量、体重。
AIM: To investigate the relationship between serum ghrelin level and body composition including bone mineral content (BMC), fat mass(FM) & lean mass(LM) in premenopausal women with different thyroid functional status. METHODS: We measured the serum ghrelin levels by radioimmunoassay (RIA), the serum levels of free triiodo- thyronine ( FT3 ), free thyroxine ( FT4 ) and sensitive thyroid - stimulating hormone (sTSH) by chemiluminescene immune assay. The total body composition including total BMC, FM and LM was measured by dual - energy X - ray absorptiometry (DXA) in 71 premenopausal women with different thyroid functional status (33 hyperthyroidism, 18 hypothyroidism and 20 normal subjects). RESULTS: (1) The level of serum ghrelin in patients with hyperthyroidism was significantly lower than that in patients with hypothyroidism (P 〈 0. 01 ) and normal subjects (P 〈 0. 01 ), but the serum ghrelin level in patients with hypothyroidism patients was similar to that in normal subjects ( P 〉 0. 05 ). The serum ghrelin level was correlated negatively with FT3 ( r = - 0. 318, P 〈 0. 01 ) and FT4 ( r = - 0. 350, P 〈 0. 01 ), simultaneously correlated positively with serum sTSH ( r =0. 281, P 〈0. 05). (2) The serum ghrelin level in 71 premenopausal women with different thyroid functional status correlated positively with the total BMC ( r = 0. 284, P 〈 0. 05 ), the total LM ( r = 0. 259, P 〈 0. 05 ), body weight ( r = 0. 279, P 〈 0.05 ) but there was not correlation with total FM (P 〉 0. 05 ). CONCLUSION : The serum ghrelin level in the premenopausal women with different thyroid functional status may correlate with the total BMC, LM and body weight.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2010年第7期1370-1374,共5页
Chinese Journal of Pathophysiology
基金
广东省医学科研基金资助项目(No.A2008354)