产后忧郁、产后抑郁患者雌二醇、孕酮和瘦素水平变化的研究

Study on the levels of Estradiol,Progesterone and Leptin of the patients with postpartum melancholia and depression

目的:探讨血清雌二醇(E2)、孕酮(P)和瘦素(Leptin)水平变化与产后忧郁、产后抑郁的关系。方法:使用爱丁堡产后抑郁量表和产后抑郁症诊断标准进行诊断,随访500例孕产妇,测定并分析产后忧郁50例、非忧郁50例、产后抑郁16例和非抑郁18例孕产妇的产前、产后及产后42天血清E2、P和Leptin水平。结果:产后忧郁患者的产后E2、P水平明显低于对照组(P<0.01,P<0.05),产后Leptin水平高于对照组(P<0.05);产后抑郁患者的产后42天E2水平明显低于对照组(P<0.05),产后与产后42天P水平差明显高于对照组(P<0.05),产后42天Leptin水平明显高于对照组(P<0.05);忧郁抑郁患者中,产后42天E2水平明显低于单纯产后忧郁患者(P<0.05),Leptin水平明显高于单纯忧郁患者(P<0.05)。结论:低水平的E2、P可能是产后忧郁的病因;低水平的E2和产后42天P下降幅度较大可能是产后抑郁的病因;高血清Leptin水平与产后忧郁、产后抑郁有关。

Objective：To detect the change of the serum levels of postpartum melancholia,postpartum depression with Estradiol （E2）,Progesterone （P） and Leptin.Methods：Using the Edinburgh Postnatal Depression Scale and Diagnostic criteria of postpartum depression for diagnosis,500 cases of pregnant and parturient women were followed-up.50 cases of postpartum melancholia,50 cases of non-postpartum melancholia,16 cases of postpartum depression and 18 cases of non-depressed patients were chosen.The levels of serum E2,Pand Leptin of them were analyzed in pregnant and post-natal women,also their post-natal 42-day Results：The levels of post-natal E2 and P of the postpartum melancholia were significantly lower than the control group （P0.01,P0.05）,while the level of post-partum Leptin was higher than the control group （P0.05）.After 42 days,the postpartum depression person＇s E2 level was significantly lower than the control group （P0.05）,thelevel of P was significantly higher than the control group （P0.05）,.the level of Leptin was significantly higher than the control group （P0.05）.Comparing with the patients of postpartum melancholia and depression,the 42-day E2 level of those patients,with postpartum melancholia only,were significantly lower than the latter（P0.05）,the level of Leptin was significantly higher than the latter （P0.05）.Conclusion：The low levels of E2 and Pmay be the reason of postpartum melancholia.The low levels of E2 and a large margin decline of the level of Pafter post-natal 42 days may be the reason of postpartum depression.The high level of serum Leptin is related to postpartum melancholia and postpartum depression.