摘要
观察了ＩＨＣ－６５对离休豚鼠心脏钙反常的影响，结果表明：ＩＨＣ－６５可使冠脉流出液中ＣＰＫ和蛋白质漏出量比钙反常组明显减少。同时升高心肌ＣＰＫ和ＧＳＨｐｘ活性，减少ＭＤＡ的生成。说明ＩＨＣ－６５对离休豚鼠心脏钙反常有保护作用。其机制可能与抑制脂质过氧化作用有关。
The aim of the present study to assess the protective effect of IHC-65 on calcium paradox in the isolated guinea pig hearts. The resultsshowed that in the treatment with IHC-65 group,the protein leakage and creatine phosphokinase(CPK ) release decreased during reper fusion andIHC-65 can attentuate the decrease in myocardial activity of CPK and glutathione peroxidase (GSHpx)also reduce the generation of malonaldehyde (MDA)in myocardium. Comparison with the calcium para-dox group, these changes were statistically significant. The results of the present study suggests thatcalcium paradox is attenuated by IHC-65 in the isolated guinea pig hearts. The protective mechanismmay be associated with the inhibition of lipid peroxi-dation.
出处
《西安医科大学学报》
CSCD
1999年第1期1-4,26,共5页
Journal of Xi'an Medical University(Chinese)
基金
国家自然科学基金!No389708392
关键词
心肌保护
豚鼠
IHC-65
钙反常
CPK
GSHPX
MDA
3
6 -dimethamidodibenzopyridonium citrate
calcium paradox
creatine phosphokinase
glu- tathione peroxidase
malonaldehyde
