2种不输液途径对奥沙利铂化疗患者神经毒性的影响

Effects of two different ways of infusion on patients with neurotoxicity caused by oxaliplatin chemotherapy

目的探讨经外周静脉置人的中心静脉导管（PICC）与外周静脉留置针输入奥沙利铂对患者造成神经毒性的差异。方法将58例拟行奥沙利铂化疗方案的消化道恶性肿瘤患者分为PICC组（n=32）和外周组（n=29），PICC组经PICC输入奥沙利铂，外周组经外周静脉留置针输入奥沙利铂，对比观察2种给药途径引起周围神经毒性反应以及药物引起肢体疼痛情况。结果PICC组出现3例神经毒性反应，均为一级，无一例出现肢体疼痛;外周组18例出现神经毒性反应，其中一级10例，二级8例，有11例出现输注侧肢体局部疼痛。PICC组神经毒性发生率明显低于外周组，差异有统计学意义（P〈0．01）。结论经PICC输入奥沙利铂，神经毒性反应轻，可避免引起肢体疼痛，有利于提高患者化疗依从性。

Objective To explore the the different effects of two different ways of infusion on patients with neurotoxicity caused by oxaliplatin chemotherapy ： peripheral inserted central catheter （PICC） vs peripheral central-vein indwelling needle （ PCVIN ）. Methods A total of 58 gastrointestinal malignancy cases reicived oxaliplatin were divided into PICC group （ n = 32 ） and PCVIN group （ n = 29 ）, incidence of toxicity and physical pain were compared. Results There were 3 cases with neurotoxicity（ all at level 1 ） and there were no cases with physical pain in PICC group, while there were 18 cases with neurotoxicity （ 10 cases at level 1 and 8 cases at level 2 ） and there were 11 cases with limb pain. The difference between groups was statistically significant （P 〈 0. 01 ）. Conclusions Oxaliplatin infusion through PICC can reduce neurotoxic reaction, decrease physical pain and improve patients＇ compliance with chemotherapy.