电刺激小脑顶核对脑卒中大鼠的治疗作用与机制

Effect and mechanism of fastigial nucleus stimulation on stroke in rats

研究电刺激小脑顶核对脑卒中大鼠的治疗作用及其机制。方法采用线栓法制备大鼠脑缺血模型，于２４ｈ测定脑血流量、脑含水量、髓过氧化物酶活性、梗塞体积；胶原酶法制备脑出血模型，于３０ｈ测定血肿周围组织含水量、脑血流量和血肿体积。结果电刺激脑缺血大鼠小脑顶核后，缺血组织的脑血流量上升，脑含水量和髓过氧化物酶活性下降，梗塞体积缩小；电刺激脑出血大鼠小脑顶核后，血肿周围组织血流量增加，含水量下降。电刺激后大鼠的生理参数和血肿体积无改变。结论电刺激小脑顶核可改善脑卒中大鼠的局部血供，缩小梗塞体积，减轻组织水肿。电刺激脑卒中大鼠小脑顶校无明显副作用。

Objective To investigate the effect and mechanism of fastigial nucleus stimulation(FNS) treating stroke in rats. Methods rCBF, water content of the brain, infarct volume andmyeloperoxidase (MPO) activity were messured in the involved tissue of ischemic rats and rCBF, thebrain water content (BWC)in the tissue arrounding hemotoma and hemotoma volume were messured inintracerebral hemorrhagic rats before and after FNS. Results in the brain ischemic rats,rCBF rose andBWC decreased and infarct volume reduced and MPO activity drop after FNS. In intracerebral hernorrhagic rats, rCBF rose and BWC decreased in the pcrihemotoma tissue and hemotoma volume did' tchange. Conclusion The protective effect of FNS on cerebral ischermic and perihemotoma tissue probably relates to the cerebral vasodilation.