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脑血管病患者血浆内皮素水平的动态变化 被引量:2

The dynamic changes of endothelin in plasma in patients with cerebrovascular disease
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摘要 目的通过对各类脑血管病(CVD)患者血浆内皮素(ET)含量的动态变化的测定观察,进一步揭示ET与各类CVD的发生、发展的关系。方法本研究动态观测了95例脑梗塞患者、57例脑出血患者及27例蛛网膜下腔出血患者血浆ET含量的变化。结果(1)各类CVD患者血浆ET水平明显高于对照组(P<0001)。(2)CVD患者发病后24h内血浆ET水平即开始升高,发病后1~3天或4~7天达高峰,半月后开始下降,1月后降至较正常水平稍高或正常。结论本研究结果表明,CVD后ET升高的过程与CVD后缺血半暗带,脑水肿及脑血管痉挛的发生时程一致。说明ET参与了CVD的发生。 Objective To observe the dynamic changes of endothelin(ET) in plasma in patients with cerebrovascular disease(CVD).Methods We measured the tends of ET levels in 95 patients with cerebral infarction,57 patients with cerebral hemorrhage and 27 patients with subarachnoid hemorrhage by radio immunoassay.Results (1)Compared to the control group,the levels of ET in plasma in patients with every CVD were elevated significantly ( P <0.001).(2)The trend of ET levels in plasma in patients with CVD were as follows:the ET levels in plasma were began to elevate within 24 hours after the onset of CVD,reach the peak on days 1~3 or 4~7,then remained high level until the end of the 2nd week,then became descended significantly on days 15 and became slightly higher than normal or normal levels on days 30.Conclusion This study shows that CVD is associated with marked elevation of plasma ET Levels.The time course of the occurrence of ischemia penumbra,brain edema,vasospasm and that of the increase in plasma ET coincided precisely.These results suggest that ET is involved in the development of CVD. [
出处 《中国急救医学》 CAS CSCD 北大核心 1999年第2期92-94,共3页 Chinese Journal of Critical Care Medicine
关键词 脑血管病 CVD 内皮素 动态变化 Cerebral infarction Cerebral hemorrhage Subarachnoid hemorrhage Endothelin Dynamic changes
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