胆囊收缩素(CCK)在冠状动脉粥样硬化斑块中的表达

The expression of CCK in atherosclerotic plaque of coronary artery of autopsy

目的揭示胆囊收缩素(CCK)在冠状动脉粥样硬化斑块中的表达情况,以进一步探讨CCK在动脉粥样硬化形成过程中的作用。方法选用100例35～92岁男性尸检冠状动脉粥样硬化标本,分为粥样硬化Ⅰ～Ⅱ级组和Ⅲ～Ⅳ级组,同时设正常对照组,用免疫组化技术进行检测。结果对照组CCK呈阴性表达,而冠状动脉粥样硬化组呈阳性表达(P<0.01),Ⅰ～Ⅱ级组与Ⅲ～Ⅳ级组之间CCK表达无显著差异(P>0.05)。结论 CCK在冠状动脉粥样硬化斑块中的有表达,但不随粥样硬化斑块程度的变化而变化。

Objective To reveal the expression of CCK in coronary artery atherosclerotic plaques,and further explore the role of CCK in the formation of coronary atherosclerosis.Methods 100 autopsy specimens of coronary atherosclerosis（35～92 years old male）were divided into atherosclerosis-level I～II and III～IV groups,and normal control group.The immunohistochemical technology was adopted.Results The expression of CCK is positive in atherosclerotic groups compare with the negative in control group（P0.01）.But it has no significant differences between I～II and III～IV groups（P0.05）.Conclusion There exists an expression of CCK in coronary atherosclerotic plaque,and dosen＇t change with the degrees of atherosclerotic plaque.