Akt与细胞线粒体凋亡途径

Relationship between Akt and mitochondria apoptotic events

在肿瘤和代谢性疾病的研究中,PI3K/Akt信号通路在线粒体功能调控中的作用日益受到重视,作为PI3K的主要下游靶蛋白,丝/苏氨酸蛋白激酶Akt在线粒体介导的内源性凋亡通路和糖酵解中发挥重要作用。本文就Akt与细胞线粒体凋亡途径的关系做一综述。

The roles of PI3K（phosphatidylinositol 3 kinase）in the regulation of mitochondrial functions in cancers and metabolic diseases are becoming interesting.Serine/threonine protein kinase Akt,the major downstream target protein of PI3K,plays an important role in the regulation of the mitochondrial apoptotic pathways and glucolysis.This review is focused on the relationship between Akt and the apoptotic pathways mediated by mitochondria.